Protein Domain : ERdj5, C-terminal thioredoxin domain IPR035674

Type	Domain
Description	ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains [ ]. This entry represents the three TRX domains located at the C-terminal half of the protein. ERdj5 is a ubiquitous protein localized in the endoplasmic reticulum (ER) and is abundant in secretory cells. It's transcription is induced during ER stress []. It interacts with BiP through its DnaJ domain in an ATP-dependent manner. BiP, an ER-resident member of the Hsp70 chaperone family, functions in ER-associated degradation and protein translocation []. Also included in this entry is the single complete TRX domain of an uncharacterized protein from Tetraodon nigroviridis.
Short Name	ERdj5_TRX_C