Protein Domain : Protein VP3, rotavirus IPR011181

Type  Family
Description  Viral protein 3 (VP3) specifically binds to GTP and contains mRNA guanylyltransferase and mRNA (guanine-N(7)-)-methyltransferase activities. It is a multifunctional enzyme involved in mRNA capping. It catalyses the formation of the 5' cap structure on the viral plus-strand transcripts [ , ]. Structure analyses revealed that it contains a variable N-terminal domain, a central guanine-N7-methyltransferase domain with an additional inserted domain, and a C-terminal guanylyltransferase and RNA 5'-triphosphatase domain. The insertion in the guanine-N7-methyltransferase domain is a ribose-2'-O-methyltransferase domain for most rotavirus species [].
Short Name  VP3_Rotav

0 Child Features

0 Gene Families

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4 Ontology Annotations

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