Protein Domain : Insulin gene enhancer protein ISL-1/2-like IPR047169

Type	Family
Description	This group of proteins includes the DNA-binding transcriptional activators insulin gene enhancer proteins ISL-1/2 (also known as Islet-1/2) and its homologues from animals [ , ]. ISL1 recognises and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes [, , ]. The early expression of ISL-1 in the developing hypothalamus determines the fate specification of melanocortinergic neurons and is essential for hypothalamic Pomc expression. It is required for melanocortin-induced satiety and normal adiposity throughout the entire lifespan []. ISL2 is a transcriptional factor that may define subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
Short Name	ISL1/2-like