Protein Domain : Rho GTPase-activating protein 17/44/SH3BP1-like IPR047165

Type	Family
Description	This entry represents a group of GTPase-activating proteins (GAPs) that stimulate the GTPase activity of Rho-type GTPases, including Rho GTPase-activating protein 17 (RHG17, also known as RICH-1), RHG44 (also known as RICH-2), SH3 domain-binding protein 1 (SH3BP1) and bargin from human which are referred to as BAR-domain RhoGAP subfamily [ ]. Bargin is an alternative splice product consisting of a modified N-terminal BAR domain, an intermediary RhoGAP domain, and a C-terminal partial CIN module and this is the only BAR-RhoGAP subfamily member that lacks a C-terminal polyproline-rich repeat region, which is replaced by the partial CIN phosphatase module [].These proteins convert GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. SH3BP1 specifically inactivates RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration [ ]. It is involved in actin remodelling and the formation of epithelial cell junctions, through negative regulation of CDC42 [, ]]. This protein plays a specific role in phagocytosis of large particles as it is specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, where it inactivates RAC1 and/or CDC42 allowing the reorganization of the actin cytoskeleton required for engulfment [].
Short Name	RHG17/44/SH3BP1-like