Protein Domain : OX-2 membrane glycoprotein-like IPR047164

Type	Family
Description	This entry represents OX-2 membrane glycoprotein (OX2G) from humans and other vertebrates and its viral homologues, including OX-2 membrane glycoprotein homologue (OX2V) from Human herpesvirus 8 (HHV-8). Member of this protein family show two immunoglobulin domains. OX2G, also known as CD200, co-stimulates T-cell proliferation. It may regulate myeloid cell activity in a variety of tissues [ , , ]. It is involved in regulation of macrophage function []. Interaction of CD200 with its receptor acts to suppress inflammatory responses [, , , ]. This protein has been shown to play important roles in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss [ ]. OX2V is encoded by herpesvirurses and has significant homology with cellular OX2. Viral OX2 encodes a glycosylated cell surface protein which has been shown to target myeloid-lineage cells [ ].
Short Name	OX2G-like