Protein Domain : ARF GTPase-activating protein Git-like IPR047161

Type	Family
Description	This entry represents ARF GTPase-activating protein Git from Drosophila melanogaster, ARF GTPase-activating protein GIT1/2 from humans, and similar proteins from animals. Git is a GTPase-activating protein for ADP ribosylation factor family members, including ARF1. It promotes proper muscle morphogenesis and proper guidance and targeting of subsets of myotubes [ ]. Git may be important for brain development []. GIT1 plays an important role in dendritic spine morphogenesis and synapse formation [, ]. It plays a crucial role in regulating GABA(A) receptor synaptic stability, leading to F-actin stabilization []. It may also may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells, eventually leading to enhanced production of VEGFA and other angiogenic factors [].
Short Name	GIT-like