Protein Domain : Caudal homeobox IPR047152

Type	Family
Description	This entry represents the caudal homeobox family, which includes homeotic protein caudal from Drosophila melanogaster (Cad), homeobox protein CDX-1 from human and similar proteins found in animals and some fungal species. Cad is a transcription factor involved in processes such as anterior/posterior patterning formation, organ morphogenesis and innate immune homeostasis. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora [ , , ]. CDX-1, is also involved in transcriptional regulation []. It may play a role in the terminal differentiation of the intestine. It binds preferentially to methylated DNA [].This entry also includes homeobox protein pal-1 from Caenorhabditis elegans, a transcriptional activator required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development [ , ].
Short Name	Caudal_homeobox