Protein Domain : Zinc phosphodiesterase ELAC protein 2-like IPR047151

Type	Family
Description	This family represents a group of zinc phosphodiesterases including zinc phosphodiesterase ELAC protein 2 (RNZ2/ELAC2, also known as ElaC homologue protein 2 and tRNase Z 2) from human and its homologues. RNZ2 has mitochondrial tRNA 3'-processing endonuclease activity. It is involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA, playing an essential role in the production of mature tRNAs [ , , ]. The homologue from Drosophila has some tRNA 3'-processing endonuclease activity of nuclear and mitochondrial pre-tRNA. It may participate in tRNA processing in the developing embryo []. Mutations in this protein have been associated with severe form of infantile cardiomyopathy [] and and prostate cancer []. The homologue from C. elegans HOE-1 has been shown to compromise fertility [, ].
Short Name	RNZ2-like