Protein Domain : F-box only protein 5/43 IPR047147

Type	Family
Description	This entry represents F-box only protein 5 and 43 (FBX5/43, also known as Emi1/Emi2, respectively [ ]) from human and similar proteins from animals. FBX5 is a regulator of the anaphase-promoting complex (APC) activity during mitotic and meiotic cell cycle [, , , , , ]. It promotes migration and osteogenic differentiation of mesenchymal stem cells []. FBX43 is required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. This protein acts by inhibiting the APC/cyclosome ubiquitin ligase. It probably recognises and binds to some phosphorylated proteins and promotes their ubiquitination and degradation [, ].
Short Name	FBX5_43