Protein Domain : JNK-interacting protein 1 IPR047178

Type	Family
Description	This entry represents the JNK (c-Jun N-terminal kinase)-interacting proteins (JIP) scaffold family, a group of scaffold proteins that regulate signalling by stress-activated MAPKs (mitogen-activated protein kinase) [ ], including C-Jun-amino-terminal kinase-interacting protein 1/2 from humans (JIP1/2). These proteins selectively mediate JNK signalling by aggregating specific components of the MAPK cascade to form a functional JNK signalling module and are required for JNK activation in response to excitotoxic stress []. They regulate the activation of MAPK8/JNK1 and differentiation of CD8+ T-cells []. JIP-1 from Drosophila melanogaster, also known as JNK-interacting protein 1, is known to play roles in fast axonal transport that are important for neuron structure and function []. Members of this family are found in animals.
Short Name	JIP1_scaffold