Protein Domain : C4-dicarboxylate transport protein IPR023954

Type	Family
Description	It has been shown [ ] that integral membrane proteins that mediate the uptakeof a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functionalsimilarities into a number of distinct families. One of these families [ ] isknown as the sodium:dicarboxylate symporter family (SDF). Such re-uptake of neurotransmitters from the synapses, is thought to be an important mechanism for terminating their action, by removing these chemicals from the synaptic cleft, and transporting them into presynaptic nerve terminals, and surrounding neuroglia. this removal is also believed to prevent them accumulating to the point of reaching neurotoxic [ , ].The structure of these transporter proteins has been variously reported to contain from 8 to 10 transmembrane (TM) regions, although 10 now seems tobe the accepted value.This entry represents cell membrane proteins which are responsible for the transport of dicarboxylates such assuccinate, fumarate, and malate from the periplasm across the membrane [ ]. They belong to the sodium:dicarboxylate (SDF) symporter(TC 2.A.23) family.
Short Name	C4_dicarb_transport