Protein Domain : Swarming motility protein SwrA IPR035388

Type	Family
Description	SwrA is a transcription factor involved in swarming motility (a multicellular movement of hyper-flagellated cells on a surface). It acts synergistically with DegU to drive the fla/che operon encoding flagella components, chemotaxis constituents and the alternative sigma factor sigmaD, which is regarded as the primary event in the development of motility [ ]. LonA protease of Bacillus subtilis inhibits SwrA by proteolytically restricting its accumulation []. SwrA does not contain any known DNA binding domain, and it has been shown to interact with the N-terminal domain of DegU. Anecdotally, in most laboratory strains, e.g. 168, the swrA coding sequence contains a nucleotide insertion that prematurely interrupts its reading frame, causing a non-swarming phenotype strain [].
Short Name	SwrA