Protein Domain : Replication protein 1a, necrotic phentoype-determining domain IPR021002

Type  Domain
Description  Replication protein 1a is a core component of the viral replicase complex in Cucumber mosaic virus and related plant viruses. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic [ ]. This entry represents a domain within replication protein 1a that appears to determine the necrotic phenotype of the virus. This domain is found in association with and . Conversion of a single arginine residue within this region (Arg461) to cysteine is sufficient to convert a non-necrotic strain to a necrotic type, and vice versa [ ]. Deletion of residue 461 leads to a loss of replicase activity in the 1a protein.
Short Name  1a_necrotic_phenotyp-det_dom

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

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