Protein Domain : 5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB IPR023858

Type  Family
Description  Members of this protein family include HmdB, a partially characterised radical SAM protein with an unusual CX5CX2C motif. The colocalization of hmdB and hmdC with hmdA (which functions in the reversible reduction of methenyl-tetrahydromethanopterin to methylene-H4MPT and H+) in the genomes of hydrogenotrophic methanogens, coupled with the similar evolutionary histories observed for deduced amino acid sequences for hmdA, hmdB, and hmdC, suggests that the genes are likely involved in a common process. This argument is bolstered by the observation that homologues of HmdB and HmdC were identified only in the genomes of hydrogenotrophic methanogens that contained hmdA. The exact function of HmdB is currently not known, although it is postulated to be involved in the biosynthesis of the HMD cofactor [ ].
Short Name  RSAM_HmdB

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