Protein Domain : A-kinase-interacting protein 1 IPR033214

Type  Family
Description  AKIP1 regulates the effect of the cAMP-dependent protein kinase (PKAc) signalling pathway on the NF-kB activation cascade [ , ]. AKIP1 binds PKA [] and co-localises with the NF-kB subunit p65 []. In humans, there are three splice variants, whereas only the full-length protein is present in rodents []. AKIP1 seems to act as a modulator of PKA in NF-kappaB signalling; different splice variants have been shown to repress [] or enhance NF-kB transcription [].
Short Name  AKIP1

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1 Ontology Annotations

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