Protein Domain : Sequence-specific single-strand DNA-binding protein IPR008116

Type	Family
Description	The sequence-specific single-strand DNA-binding protein (SSDP) family is thought to be involved in transciption regulation. SSDP specifically bindssingle-stranded pyrimidine-rich mirror repeat elements commonly found in promoter regions, and is believed to regulate alpha-2(I) collagen [ ]. Ithas been identified as a target for unbalanced translocations and deletions in acute myelogenous leukemia cells, implying a role as a tumour suppressorgene. It is expressed in spleen, lymph node, peripheral blood, bone marrow, thymus and foetal liver. Family members have been identified inchicken, human, rat, mouse and Drosophila. The highest sequence identity is observed in the first 100 N-terminal residues, which contains a tryptophan-rich region in its centre. The C terminus is more viariable, with glycine/proline-rich low complexity regions.
Short Name	SSDP_DNA-bd