Protein Domain : Ataxin2-like IPR045117

Type	Family
Description	This entry represents a group of RNA-binding proteins , including Ataxin-2 from animals, Pbp1 from fungi and Cid3/4 from Arabidopsis. Ataxin-2 has many functions, such as endocytic receptor cycling [ ], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation [] and forms a condensate in response to respiratory status to regulate TORC1 signalling []. It is also involved in P-body-dependent granule assembly [].Cid3/4 may have a role in developmental pathways throughout the life cycle of plants [ ].
Short Name	ATXN2-like