Protein Domain : Hobbit IPR045167

Type	Family
Description	This entry includes Hobbit protein from Drosophila melanogaster and its homologues such as Bridge-like lipid transfer protein family member 2 from human (BLTP2/KIAA0100) and FMP27 from yeast, referred to the Hob proteins [ , ]. These proteins are localized to endoplasmic reticulum-plasma membrane (ER-PM) contact sites described as conserved lipid-binding proteins. They have a long hydrophobic groove and can mediate bulk transport of lipids between organelles. This entry also includes maize protein APT1 and Arabidopsis homologues SABRE and KIP []. The Hob family belongs to the repeating β-groove (RBG) superfamily together with VPS13, ATG2, SHIP164, Csf1/BLTP1, which are all conserved lipid transfer proteins containing long hydrophobic grooves []. They all share the same structure consisting of multiple repeating modules consisting of five β-sheets followed by a loop. The function of the FMP27 (Found in mitochondrial proteome protein 27) is tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution [ , ]. APT1 (Aberrant pollen transmission 1) is required for pollen tube growth. It is a Golgi-localised protein and appears to regulate vesicular trafficking []. SABRE (Hypersensitive to Pi starvation 4) and KIP (Kinky pollen) are APT1 homologues and they are involved in the elongation of root cortex cells and pollen tubes respectively.
Short Name	Hobbit