Protein Domain : Exportin-5, C-terminal domain IPR045478

Type	Domain
Description	This entry represents the C-terminal domain found in eukaryotic proteins such as Exportin-5 from mammals, HASTY 1 from Arabidopsis and Msn5 from yeasts. Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). It also mediates the nuclear export of micro-RNA precursors, which form short hairpins and micro-RNA precursors, which form short hairpins and, in some circumstances, it can also mediate the nuclear export of deacylated and aminoacylated tRNAs. [ , , , ]. Exportin-5 yeast homologue, also known as Msn5 [ ], is involved in nuclear import of replication protein A and export of various proteins, including transcription factors such as Pho4 []. Its Arabidopsis homologue, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs) and plays a role in plant development through its role in miRNAs processing [, ].
Short Name	Exportin-5_C