Protein Domain : Small kinetochore-associated protein IPR033373

Type  Family
Description  Small kinetochore associated protein (SKAP) cooperates with kinetochore and mitotic spindle proteins to regulate the metaphase-to-anaphase transition [ , ]. Its interaction with astrin in the kinetochore is important for normal spindle architecture and chromosome alignment [, ]. It interacts with MIS13 to orchestrate accurate interaction between kinetochore and dynamic spindle microtubules []. It also interacts with mitotic motor CENP-E to orchestrate accurate chromosome segregation in mitosis []. SKAP may also promote UV-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19 [].
Short Name  SKAP

0 Child Features

0 Gene Families

0 Genes

4 Ontology Annotations

0 Parent Features

0 Publications

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