Protein Domain : Hok/gef cell toxic protein, conserved site IPR018084

Type	Conserved_site
Description	The hok/gef family of Gram-negative bacterial proteins are toxic to cells when over-expressed, killing the cells from within by interfering with avital function in the cell membrane [ ]. Some family members (flm) increase the stability of unstable RNA [], some (pnd) induce the degradation of stable RNA at higher than optimum growth temperatures [], amongst others, affect the release of cellular magnesium by membrane alterations []. Theproteins are short (50-70 residues), consisting of an N-terminal hydrophobic (possibly membrane spanning) domain, and a C-terminal periplasmic region, which contains the toxic domain. The C-terminal region contains a conserved cysteine residue that mediates homo-dimerisation in the gef protein, although dimerisation is not necessary for the toxic effect [ ].This entry represents a conserved region found within these proteins.
Short Name	Hok/gef_toxin_CS