Protein Domain : Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily IPR043035

Type  Homologous_superfamily
Description  This superfamily represents a domain found in proteins which act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity [ ]. They may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.Structurally, this domain consists of 4 alpha helices.
Short Name  Damage-induce-interact_sf

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