Protein Domain : Flagellum site-determining protein FlhG IPR033875

Type	Domain
Description	FlhG (also annotated FleN/YlxH) is an ATPase that regulates location and number of bacterial flagella [ , , , ]. FlhG acts antagonistically with FlhF/FleQ to regulate the number of polar flagella, with FlhF promoting flagellar assembly and FlhG inhibiting it. FlhG interacts with FlhF and influences its GTPase activity [, ].FlhG and FlhF are responsible for generating the single polar flagellum of Pseudomonas sps and Vibrio cholerae. In these bacteria, FlhG represses the activity or expression of a master transcriptional regulator [ ], FleQ in the case of Pseudomonas [, ]. Campylobacter jejuni FlhG likely influences a flagellar biosynthetic step to control flagellar number, rather than suppressing activators of flagellar gene transcription as in Vibrio and Pseudomonas species []. On the peritrichous bacterium Bacillus subtilis, FlhF and FlhG function together to spatially organize flagella in a defined grid-like pattern around the cellular midpoint, but not at polar regions [].
Short Name	FlhG