Protein Domain : Astrovirus VPg protein IPR045836

Type	Family
Description	This entry represents the presumed VPg protein from human astrovirus. Viral genome-linked proteins (VPgs) are virus-encoded small proteins that are covalently linked to the 5' terminus of many RNA viral genomes through a phosphodiester bond. Viral genome-linked proteins (VPgs) have been identified in several single-stranded positive-sense RNA virus families. The protein resulting from this putative VPg coding region is a highly disordered protein [ ]. A common feature of VPgs is that they are rich in basic amino acids [mostly Lys (K), Gly (G), Thr (T), and Arg (R)], which favors the interaction with the negatively charged RNA. Tyr-693 at the conserved TEEEY-like motif has been postulated to be the residue responsible for the covalent linkage to viral RNA. Mutagenesis of Tyr-693 in the VPg protein is lethal for HAstV replication [ ].
Short Name	Astro_VPg