Protein Domain : RNA-binding protein ZFP36-like IPR045877

Type	Family
Description	This entry represents a group of CCCH-type zinc finger proteins, including ZFP36/ZFP36L1/ZFP36L2 from animals, Zfs1 from fission yeasts and CTH1/2 from budding yeasts. ZFP36/ZFP36L1/ZFP36L2, Zfs1 and CTH1/2 are mRNA decay activator proteins that bind to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation [ , , ]. Interestingly, ZC3H11 from Trypanosoma brucei brucei, also included in this entry, binds AU-rich regions in the 3'-UTR of mRNAs and promotes their stabilisation by recruiting a MKT1-containing complex [, ].This entry also includes some uncharacterised plant CCCH-type zinc finger proteins, among which Arabidopsis HUA1 may be involved in RNA processing [ ].
Short Name	ZFP36-like