Protein Domain : Mitochondrial dynamics protein MID49/MID51 IPR045909

Type  Family
Description  This entry represents the mitochondrial dynamics protein MID49/MID51. Most members of this protein family contain a Mab-21 domain and are found in chordates.In humans, MID49 and MID51 are outer membrane proteins involved in the regulation of mitochondrial organisation and required for mitochondrial fission by promoting the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. They also regulate DNM1L GTPase activity [ , , , , ]. Deregulation of these proteins has been linked to human diseases such as pulmonary arterial hypertension [].
Short Name  MID49/MID51

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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