Protein Domain : Wnt protein, conserved site IPR018161

Type	Conserved_site
Description	Wnt-1 (previously known as int-1) [ ] is a proto-oncogene induced by theintegration of the mouse mammary tumor virus. It is thought to play a role in intercellular communication and seems to be a signalling molecule important inthe development of the central nervous system (CNS). The sequence of wnt-1 is highly conserved in mammals, fish, and amphibians.Wnt-1 is a member of a large family of related proteins [ , ] that are allthought to be developmental regulators. These proteins are known as wnt-2 (also known as irp), wnt-3 up to wnt-15. At least four members of this familyare present in Drosophila; one of them, wingless (wg), is implicated in segmentation polarity.All these proteins share the following features characteristics of secretory proteins: a signal peptide, several potential N-glycosylation sites and 22conserved cysteines that are probably involved in disulfide bonds. The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and aretherefore likely to signal over only few cell diameters.Signal transduction by the Wnt family of ligands is mediated by the binding to the extracellular domain fz of Frizzled receptors. It can lead to either theactivation of dishvelled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes or be coupledto the inositol signaling pathway and PKC activation, depending on the type of Frizzled receptor [, ].This entry represents a conserved region including three cysteines.
Short Name	Wnt_CS