GO Term : GO:0070266 necroptotic process Gene Ontology

Description  A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
Namespace  biological_process
Obsolete  false

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0 Data Sets

1 Ontology

Trail: GOTerm

0 Ontology Annotations

7 Parents

Trail: GOTerm

17 Relations

Trail: GOTerm

20 Synonyms

Trail: GOTerm
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