Protein Domain : Elongator complex protein 5 IPR019519

Type  Family
Description  Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [ , ]. It consists of two subcomplexes, a core subcomplex (ELP1-3), and an accessory subcomplex (ELP4-6) []. The elongator complex has been associated with many cellular activities, including transcriptional elongation [, ], but its main function is tRNA modification [, ]. It is required for the formation of 5-methoxy-carbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups on uridine nucleosides present at the wobble position of many tRNAs [].This entry represents Elongator complex protein 5 (ELP5).
Short Name  Elp5

0 Child Features

2 Gene Families

11 Genes

2 Ontology Annotations

0 Parent Features

4 Publications

USDA
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