Protein Domain : FMP27/BLTP2/Hobbit, GFWDK motif-containing RBG unit IPR019441

Type	Domain
Description	This entry includes Hobbit protein from Drosophila melanogaster and its homologues such as Bridge-like lipid transfer protein family member 2 from human (BLTP2/KIAA0100) and FMP27 from yeast, referred to the Hob proteins [ , ]. These proteins are localized to endoplasmic reticulum-plasma membrane (ER-PM) contact sites described as conserved lipid-binding proteins. They have a long hydrophobic groove and can mediate bulk transport of lipids between organelles. This entry also includes maize protein APT1 and Arabidopsis homologues SABRE and KIP []. The Hob family belongs to the repeating β-groove (RBG) superfamily together with VPS13, ATG2, SHIP164, Csf1/BLTP1, which are all conserved lipid transfer proteins containing long hydrophobic grooves []. They all share the same structure consisting of multiple repeating modules consisting of five β-sheets followed by a loop. The function of the FMP27 (Found in mitochondrial proteome protein 27) is tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution [ , ]. APT1 (Aberrant pollen transmission 1) is required for pollen tube growth. It is a Golgi-localised protein and appears to regulate vesicular trafficking []. SABRE (Hypersensitive to Pi starvation 4) and KIP (Kinky pollen) are APT1 homologues and they are involved in the elongation of root cortex cells and pollen tubes respectively.This entry represents a RBG module containing the conserved GFWDK sequence motif.
Short Name	FMP27/BLTP2/Hobbit_GFWDK_RBG