v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | This entry represents a domain found at the C terminus of chromodomain-helicase-DNA-binding proteins, including Chromodomain-helicase-DNA-binding protein 1 from human (CHD1), an ATP-dependent chromatin-remodeling factor which acts as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. This protein functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 [ , ]. This helical domain, which is also found in CHD1 helical C-terminal domain-containing protein 1 (also known as C17orf64) from mammals [], consists of five α-helices organised in a variant helical bundle topology. Its surface is positively charged and can bind dsDNA and nucleosomes, but its specific function remains unknown []. |
| Short Name | CHD1-like_C |