Protein Domain : rRNA 2'-O-methyltransferase fibrillarin-like IPR000692

Type	Family
Description	rRNA 2'-O-methyltransferase fibrillarin (Fibrillarin) is a component of a nucleolar small nuclear ribonucleoprotein (SnRNP) [ , ]. It is a S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Site specificity is provided by a guide RNA that base pairs with the substrate and methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA [, , , , ]. Fibrillarin is associated with U3, U8 and U13 small nuclear RNAs in mammals [] and is similar to the yeast NOP1 protein []. It has awell conserved sequence of around 320 amino acids, and contains 3 domains, an N-terminal Gly/Arg-rich region; a central domain resembling other RNA-binding proteins and containing an RNP-2-like consensussequence; and a C-terminal α-helical domain. An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaebacteria.
Short Name	Fibrillarin