Protein Domain : Trypanosoma cruzi ribosomal protein P2-like IPR001859

Type	Family
Description	Eukaryotic ribosomal P proteins have been classified according to their similarity to the mammalian P0, P1 and P2 proteins [ ], all of which share a similar primary structure: an apparently globular N-terminal domain (which includes the protein core); an Ala-rich hinge region; and a highly-acidic Glu/Asp-rich C-terminal domain - this contains the ribosomal P consensus sequence EESDDDMGFGLFD, which protrudes from the ribosomal stalk.The C-terminal regions of Trypanosoma cruzi P proteins are strongly immunogenic in Chagas disease. All 3 forms of the protein show the ability to generate autoimmune responses, but their antigenic properties differ as a result of discrepancies in their C-terminal sequences []. The main linear epitope of the T. cruzi P1 and P2 proteins has been mapped to the 13-residue C-terminal sequence (R-13) EEEDDDMGFGLFD. This is identical to the eukaryotic P consensus, but has Ser substituted by Glu, yielding a more hydrophilic sequence, which is critical in determining the immunological reactivity of the T. cruzi R-13 epitope in Chagas disease.This entry represents a family of T.cruzi P2 ribosomal proteins. It also matches P2 proteins from different organisms or closely-related ribosomal P1 proteins.
Short Name	T.cruzi_P2-like