Protein Domain : Telomere length and silencing protein 1-like IPR010756

Type  Family
Description  Tls1 in fission yeast is required for telomeric heterochromatin assembly as well as telomere length control [ , ]. The human homologue, the splicing factor C9orf78 (also known as hepatocellular carcinoma-associated antigen 59), plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites []. It may also modulate exon inclusion events and plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity [, ]. C9orf78 is required for proper chromosome segregation [].
Short Name  Tls1-like

0 Child Features

1 Gene Families

6 Genes

0 Ontology Annotations

0 Parent Features

4 Publications

USDA
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