Protein Domain : Insulin-induced protein family IPR025929

Type  Family
Description  This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations [ , ].The INSIG family also includes NSG1 and NSG2 (INSIG homologues 1 and 2) [ ].
Short Name  INSIG_fam

0 Child Features

0 Gene Families

6 Genes

0 Ontology Annotations

0 Parent Features

2 Publications

USDA
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