Protein Domain : CLU domain containing protein IPR027523

Type	Family
Description	This entry includes protein clueless from Drosophila, Clu1 from yeasts and protein CLU from plants. They are involved in proper cytoplasmic distribution of mitochondria [ , ].Protein clueless from Drosophila is required for mitochondrial subcellular localisation, interacts genetically with parkin [ ]. It is highly expressed in larval neuroblasts, affects mitochondrial localisation and suppresses mitochondrial oxidative damage [].Budding yeast Clu1 is a subunit of the eukaryotic translation initiation factor 3 (eIF3). It can influence mitochondrial morphology and distribution [ ]. Arabidopsis CLU, also known as FRIENDLY (At3g52140), is involved in regulating intermitochondrial association, a prelude to mitochondria fusion [ , ]. FRIENDLY may have expanded into a small gene family to help manage the energy metabolism of cells that contain both chloroplasts and mitochondria. These homologue are known as REDUCED CHLOROPLAST COVERAGE (REC) 1/2/3 (AT1G01320 , AT4G28080, AT1G15290). Together, they contribute to establishing the size of the chloroplast compartment [ ].
Short Name	CLU_prot