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Search results 38701 to 38750 out of 38750 for *

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR022575
Name: Neurogenic differentiation factor, domain of unknown function
Type: Domain
Description: This domain is found in Neurogenic differentiation factor 1 from Mus musculus (NeuroD1) and similar proteins from animals. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development and its absence leads to serious diseases [ , , , ]. This domain is found C-terminal to the less specific helix-loop-helix DNA binding domain .
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Protein Domain
IPR046535
Name: Protein of unknown function DUF6600
Type: Family
Description: This entry represents a bacterial protein of unknown function. It is rich in conserved tryptophan residues and contains a central HYGRW motif that may be of functional importance.
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Protein Domain
IPR022578
Name: Flagellin, D2 domain
Type: Domain
Description: This entry represents the variable D2 domain found in uncharacterised proteins from Betaproteobacteria, including Flagellin from Burkholderia pseudomallei (FliC, ), an important subunit vaccine candidate for the serious infectious disease melioidosis. FliC assembles to form the flagellar filament that supports bacterial motility [ , ]. This domain is found in association with , .
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Protein Domain
IPR046534
Name: Protein of unknown function DUF6599
Type: Family
Description: This entry represents a family of uncharacterised bacterial proteins.
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Protein Domain
IPR046533
Name: Protein of unknown function DUF6598
Type: Domain
Description: This domain is found at the C-terminal of several plant proteins, including 60 kDa jasmonate-induced protein and in some fungal sequences. The function of the domain is unknown.
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Protein Domain
IPR046532
Name: Protein of unknown function DUF6597
Type: Domain
Description: This presumed domain is found at the N-terminal of bacterial transcription factor proteins, including the uncharacterised HTH-type transcriptional regulator in mcrB 3'region from Streptomyces lavendulae, suggesting that this may be a regulatory domain that binds to some as yet unknown ligand.
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Protein Domain
IPR022579
Name: Neuropilin, C-terminal
Type: Domain
Description: This domain of unknown function is located in the C terminus of the eukaryotic neuropilin receptors. There are two completely conserved residues (Y and E) that may be functionally important. Neuropilins are essential multifunctional vertebrate cell surface receptors [ ]. They function as receptors for axon guidance factor semaphorin class 3 (Sema3), vascular endothelial growth factor (VEGF) and placenta growth factor-2 (PLGF-2).
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Protein Domain
IPR046531
Name: Domain of unknown function DUF6596
Type: Domain
Description: This presumed domain is found towards the C-terminal of bacterial RNA polymerase ECF sigma factor proteins.
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Protein Domain
IPR046530
Name: Copper acquisition factor BIM1-like domain
Type: Domain
Description: This domain is found in fungal proteins, including copper acquisition factor BIM1 from Cryptococcus neoformans, a cell surface-bound protein that functions in the copper-accumulation pathway shared by the CUF1-dependent copper transporter CTR1 [ , ]. BIM1 facilitates copper acquisition in the brain of mammalian hosts and acts as a copper-dependent virulence trait in fungal meningitis []. This domain has a lytic polysaccharide monooxygenase-like (LPMO) fold, which are evolutionarily related but have diverged to a different biological function.
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Protein Domain
IPR010581
Name: Protein of unknown function DUF1152
Type: Family
Description: This family consists of proteins of unknown function.
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Protein Domain
IPR034551
Name: Mucin-20
Type: Family
Description: Mucin-20 (MUC20) was identifiied as a gene that is up-regulated in the renal tissues of patients with immunoglobulin A nephropathy [ ]. It is a regulator of the Met signaling cascade. MUC20 associates with Met which is the hepatocyte growth factor (HGF) receptor, and has a role in suppressing the Grb2-Ras pathway. Production of MUC20 reduced HGF-induced matrix metalloproteinase expression and proliferation, which require the Grb2-Ras pathway [].
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Protein Domain
IPR034553
Name: Mitochondrial import receptor subunit TOM5 homologue, viridiplantae
Type: Family
Description: Protein import into the mitochondria involves several translocase complexes: the preprotein translocase of the outer mitochondrial membrane (TOM complex) and the two preprotein translocases of the inner mitochondrial membrane (called TIM complexes).TOM5 is a component of the TOM complex. This entry represents TOM5 from the plant complex, which consist at least of six subunits [ , ].
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Protein Domain
IPR010583
Name: MltA-interacting MipA
Type: Family
Description: This family consists of several bacterial MltA-interacting protein (MipA) like sequences. As well as interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex [ ].
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Protein Domain
IPR034554
Name: Mitochondrial import receptor subunit TOM6 homologue, plants
Type: Family
Description: Protein import into the mitochondria involves several translocase complexes: the preprotein translocase of the outer mitochondrial membrane (TOM complex) and the two preprotein translocases of the inner mitochondrial membrane (called TIM complexes).This entry represents TOM6 from the plant TOM complex, which consist at least of six subunits [ , ].
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Protein Domain
IPR010584
Name: Exodeoxyribonuclease 8
Type: Family
Description: This represents the exodeoxyribonuclease 8 (EXO VIII) proteins from Enterobacteriaceae. Exonuclease VIII from Escherichia coli is involved in the RecE pathway of recombination and has been shown to preferentially degrade linear duplex DNA [ ].
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Protein Domain
IPR034545
Name: Meiosis-specific kinetochore protein
Type: Family
Description: The meiosis-specific kinetochore factor Meikin plays a crucial role in both mono-orientation and centromeric cohesion protection during meiosis I, partly by stabilizing the localization of the cohesin protector shugoshin, and also by recruiting Polo-like kinase PLK1 to the kinetochores. PLK1 is required for mono-orientation and the protection of centromeric cohesion [].
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Protein Domain
IPR034546
Name: Protein PAIR1
Type: Family
Description: The representative of this plant family is PAIR1 (HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS1), a protein that plays an essential role in establishment of homologous chromosome pairing in meiosis. Mutations in the gene encoding this protein also affect spindle formation and sporulation [ ]. This family also contains the Putative recombination initiation defects 3 (AtPRD3) involved in the meiotic recombination initiation [].In flowering plants, gametophyte formation relies on meiosis. In meiosis I, the homologous chromosomes are separated into two daughter cells. In meiosis II, the sister chromosomes are then separated into newly formed daughter cells. During prophase I, several events occurs: sister chromatid cohesion, homologous chromosome synapsis, recombination, crossover formation and chromosome segregation. Homologous recombination is initiated from the formation of DNA double-strand breaks (DSBs). The formation of DSBs is catalyzed by Spo11 and its homologues. So far, six Arabidopsis proteins, AtSPO11-1, AtSPO11-2, AtPRD1, AtPRD2, AtPRD3 and AtDFO, have been shown to be involved in DSB formation [].
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Protein Domain
IPR010598
Name: D-glucuronyl C5-epimerase, C-terminal
Type: Domain
Description: This entry represents the C terminus conserved region of known or predicted D-glucuronyl C5-epimerases. D-glucuronyl C5-epimerase converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains [ , ].
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Protein Domain
IPR034547
Name: Tte1186a maturase
Type: Family
Description: Tte1186 catalyzes the formation of a thioether cross-link in the peptide Tte1186a, which is encoded by an orf located upstream of the maturase, under reducing conditions in the presence of SAM. Tte1186 contains three [4Fe-4S] clusters that are indispensable for thioether cross-link formation; however, only one cluster catalyzes the reductive cleavage of SAM [].
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Protein Domain
IPR010599
Name: Connector enhancer of kinase suppressor of ras 2/3 domain
Type: Domain
Description: This region is found in Connector enhancer of kinase suppressor of ras 2 (CNK2), Connector enhancer of kinase suppressor of ras 3 (CNK3) and CNK3/IPCEF1 fusion protein. This domain of unknown function is situated between the PDZ and PH domains in CNK2 and CNK3/IPCEF1 proteins and after the PDZ domain in CNK3 (which does not have a PH domain). CNK2 is predominantly expressed in neural tissues, being critical for postsynaptic density morphology, implicated in X-linked intellectual disability (ID). CNK2 was first described as a regulator of Ras/MAPK signalling by binding to the Ras effector RAF that lead to further studies concluding that it act as a scaffold for multiple signal cascades. It is able to direct the localisation of regulatory proteins within the cell and influences the behaviour of important regulatory molecules [ , ]. CNK3 regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression, acting as a scaffold protein that coordinates the assembly of an ENaC-regulatory complex (ERC) []. CNK3/IPCEF1 is required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration [].
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Protein Domain
IPR034549
Name: Sperm acrosome membrane-associated protein 6
Type: Family
Description: Spaca6 is an immunoglobulin-like sperm protein required for sperm-oocyte fusion in mice [ , ].
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Protein Domain
IPR046529
Name: Domain of unknown function DUF6594
Type: Domain
Description: This entry represents a domain found in uncharacterised fungal proteins that contain a set of C-terminal transmembrane helices. This entry may be related to .
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Protein Domain
IPR022560
Name: Domain of unknown function DUF3473
Type: Domain
Description: This domain, found in bacteria and archaea, is functionally uncharacterised. It is about 130 amino acids in length and is found C-terminal to . It contains two completely conserved residues (P and H) that may be functionally important.
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Protein Domain
IPR046528
Name: Domain of unknown function DUF6593
Type: Domain
Description: This entry represents a domain found in uncharacterized fungal proteins.
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Protein Domain
IPR022563
Name: Domain of unknown function DUF3463
Type: Domain
Description: This functionally uncharacterised domain is found in bacteria and archaea, which is about 140 amino acids in length and is found C-terminal to . It contains two conserved sequence motifs: CTPWG and PCYL. This domain is associated with hopanoid biosynthesis associated radical SAM proteins.
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Protein Domain
IPR046527
Name: PIR2-like, helical domain
Type: Domain
Description: This helical domain is found at the N-terminal of plant E3-ligase proteins, including PP2CA INTERACTING RING FINGER PROTEIN 2 (PIR2, also known as MND1-interacting protein 1) and its paralogues RF4 and RF298 from Arabidopsis. The function of this domain is unknown. PIR2 is the closest homologue of PIR1 (PP2CA interacting RING finger protein 1) and both positively modulate ABA signaling by targeting PP2CA for degradation [ ].
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Protein Domain
IPR022562
Name: Protein of unknown function DUF3466
Type: Family
Description: This family of bacterial proteins are functionally uncharacterised. Proteins in this family are typically between 564 to 612 amino acids in length.
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Protein Domain
IPR046526
Name: Domain of unknown function DUF6591
Type: Domain
Description: This presumed domain is functionally uncharacterised. This domain family is found in bacteria, mainly Firmicutes and Actinobacteria, and is approximately 80 amino acids in length. It contains a highly conserved tryptophan residue and the conserved sequence YxxxxxxY.
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Protein Domain
IPR022565
Name: Protein of unknown function DUF2608
Type: Family
Description: This entry represents a group of proteins predominantly found in Bacteria. The function is not known.
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Protein Domain
IPR046525
Name: Protein of unknown function DUF6702
Type: Domain
Description: This entry represents an uncharacterised family of proteins. Some members of the family are annotated as Peptidase E, but the does not appear to be any evidence to support that assertion.
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Protein Domain
IPR022564
Name: Protein of unknown function DUF2678
Type: Family
Description: This family of proteins has no known function.
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Protein Domain
IPR046524
Name: Domain of unknown function DUF6701
Type: Domain
Description: This entry represents an uncharacterised region found in a wide range of bacterial cell surface proteins.
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Protein Domain
IPR022567
Name: Glycosyl hydrolase, C-terminal (DUF3459)
Type: Domain
Description: This entry represents a conserved domain found at the C-terminal of a subset of the glycosyl hydrolase 13 family members, including from Xanthomonas campestris, which consists of two antiparallel β-sheets [ ]. The function of this domain is not clear.
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Protein Domain
IPR046523
Name: U3 small nucleolar RNA-associated protein 20, C-terminal
Type: Domain
Description: This domain is found towards the C-terminal the U3 small nucleolar RNA-associated protein 20 (UTP20) from yeast and its human homologue, also known as DRIM (Down-Regulated In Metastasis) ( ). DRIM is differentially expressed in metastatic and non-metastatic human breast carcinoma cells [ ]. Proteins of this entry are involved in processing of non-coding RNA as components of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA [ , ]. UTP20 is a huge α-solenoid that functions as a scaffold [, ].
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Protein Domain
IPR022566
Name: Protein of unknown function DUF2613
Type: Family
Description: This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.
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Protein Domain
IPR046522
Name: Protein of unknown function DUF6699
Type: Family
Description: This entry represents a family of uncharacterised fungal proteins
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Protein Domain
IPR022569
Name: Ferredoxin, C-terminal
Type: Domain
Description: This functionally uncharacterised domain is found in bacteria and is about 50 amino acids in length. It is found C-terminal to . It contains a single completely conserved residue N that may be functionally important.
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Protein Domain
IPR046521
Name: Protein of unknown function DUF6698
Type: Family
Description: This entry represents an uncharacterised family of fungal proteins.
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Protein Domain
IPR022568
Name: Protein of unknown function DUF2824
Type: Family
Description: This family of proteins has no known function. Members of the family are found in P22-like viruses and bacteria. Some of the phage members have been annotated as head assembly proteins, but this has not been confirmed.
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Protein Domain
IPR046520
Name: Protein of unknown function DUF6697
Type: Domain
Description: This entry represents a fungal domain of unknown function.
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Protein Domain
IPR010592
Name: Extracytoplasmic thiamine-binding lipoprotein
Type: Family
Description: Thiamine-binding lipoprotein (Cypl) and related proteins are specific to Mycoplasma species. Cypl, also known as p37, whose gene is part of an operon encoding two additional proteins, which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria. It has been suggested that p37 is part of a homologous, high-affinity transport system in Mycoplasma hyorhinis, a Gram-positive bacterium [ ]. Its structure indicates that it is a thiamine pyrophosphate-binding protein []. The monomer is a mixed alpha/beta fold split into two globular domains (domains I and II) connected by two linker regions and the C-terminal helix.
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Protein Domain
IPR010593
Name: Protein of unknown function DUF1159
Type: Family
Description: This entry consists of several hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR010590
Name: Protein of unknown function DUF1158
Type: Family
Description: This family consists of several enterobacterial YbdJ proteins. The function of this family is unknown
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Protein Domain
IPR010596
Name: Methuselah, N-terminal domain
Type: Domain
Description: Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [ , ]. This entry represents the N-terminal domain of the Methuselah protein.
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Protein Domain
IPR010594
Name: Autographa californica nuclear polyhedrosis virus (AcMNPV), Ac75
Type: Family
Description: This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV) protein Ac75, which is required for the egress of nucleocapsids from the nucleus, formation of intranuclear microvesicles and subsequent budded virion formation, in addition to protein Ac93. Ac75 is not an integral membrane protein, but it interacts with integral membrane protein Ac76 and is associated with the nuclear membrane [ ].
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Protein Domain
IPR034543
Name: Long chronological lifespan protein 2
Type: Family
Description: This family of yeast proteins has no known function. Mutants have a long chronological lifespan [ ] and genetic interactions suggest that LCL2/ YLR104W is a novel component of ERAD (endoplasmic reticulum-associated degradation pathway) [].
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Protein Domain
IPR010595
Name: Protein of unknown function DUF1161
Type: Family
Description: This family consists of several short, hypothetical bacterial proteins of unknown function.
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Protein Domain
IPR046599
Name: Protein of unknown function DUF6658
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 198 amino acids in length.
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Protein Domain
IPR046598
Name: Protein of unknown function DUF6657
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
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Protein Domain
IPR046597
Name: Protein of unknown function DUF6656
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
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