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Categories

Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF04818 | CID domain
Description: This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II [1,2]. This domain is known as the CTD-interacting domain (CID).
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Ontology Term
PANTHER:PTHR11627 | FRUCTOSE-BISPHOSPHATE ALDOLASE
 
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Ontology Term
Pfam:PF00274 | Fructose-bisphosphate aldolase class-I
Description: NULL
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Ontology Term
PANTHER:PTHR21470 | RAB6-INTERACTING PROTEIN GORAB
 
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Ontology Term
Pfam:PF04949 | Transcriptional activator
Description: This family of proteins may act as a transcriptional activator. It plays a role in stress response in plants [1].
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Ontology Term
Pfam:PF02806 | Alpha amylase, C-terminal all-beta domain
Description: Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.
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Ontology Term
PANTHER:PTHR12304 | INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE
 
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Ontology Term
Pfam:PF01156 | Inosine-uridine preferring nucleoside hydrolase
Description: NULL
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Ontology Term
Pfam:PF14008 | Iron/zinc purple acid phosphatase-like protein C
Description: This domain is found at the C-terminus of Purple acid phosphatase proteins.
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Ontology Term
PANTHER:PTHR21236 | GOLGI MEMBRANE PROTEIN YIP1
 
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Ontology Term
PANTHER:PTHR10072 | IRON-SULFUR CLUSTER ASSEMBLY PROTEIN
 
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Ontology Term
Pfam:PF01521 | Iron-sulphur cluster biosynthesis
Description: This family is involved in iron-sulphur cluster biosynthesis [3]. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins [1] [2].
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Ontology Term
PANTHER:PTHR30314 | CELL DIVISION PROTEIN FTSZ-RELATED
 
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Ontology Term
Pfam:PF12327 | FtsZ family, C-terminal domain
Description: This family includes the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ is a GTPase, like tubulin. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea.
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Ontology Term
PANTHER:PTHR19920 | WD40 PROTEIN CIAO1
 
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Ontology Term
PANTHER:PTHR12980 | UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X
 
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Ontology Term
PANTHER:PTHR12980:SF0 | CYTOCHROME B-C1 COMPLEX SUBUNIT 9
 
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Ontology Term
Pfam:PF05365 | Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Description: The UQCRX/QCR9 protein is the 9/10 subunit of complex III, encoding a protein of about 7-kDa. Deletion of QCR9 results in the inability of cells to grow on grow on-fermentable carbon source n yeast [1].
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Ontology Term
PANTHER:PTHR23105 | RIBOSOMAL PROTEIN L7AE FAMILY MEMBER
 
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Ontology Term
Pfam:PF00687 | Ribosomal protein L1p/L10e family
Description: This family includes prokaryotic L1 and eukaryotic L10.
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Ontology Term
PANTHER:PTHR13355 | GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR11220:SF1 | OS01G0235300 PROTEIN
 
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Ontology Term
PANTHER:PTHR11564:SF7 | SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF01020 | Ribosomal L40e family
Description: Bovine L40 has been identified as a secondary RNA binding protein [1]. L40 is fused to a ubiquitin protein [2].
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Ontology Term
Pfam:PF13844 | Glycosyl transferase family 41
Description: This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues [1,2]. In addition to its function as an O-GlcNAc transferase, human OGT, Swiss:O15294, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1 [3].
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Ontology Term
Pfam:PF06258 | Mitochondrial fission ELM1
Description: In plants, this family is involved in mitochondrial fission. It binds to dynamin-related proteins and plays a role in their relocation from the cytosol to mitochondrial fission sites [1]. Its function in bacteria is unknown.
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Ontology Term
PANTHER:PTHR16290 | TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1
 
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Ontology Term
PANTHER:PTHR16290:SF0 | DECAPPING PROTEIN 1, ISOFORM A
 
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Ontology Term
Pfam:PF06058 | Dcp1-like decapping family
Description: An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2 (Pfam:PF05026). The precise role of these proteins in the decapping reaction have not been established. Evidence suggests that the Dcp1 may enhance the function of Dcp2 [1].
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Ontology Term
PANTHER:PTHR11010 | PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED
 
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Ontology Term
Pfam:PF05577 | Serine carboxypeptidase S28
Description: These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.
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Ontology Term
PANTHER:PTHR23354 | NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED
 
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Ontology Term
Pfam:PF07534 | TLD
Description: This domain is predicted to be an enzyme [1] and is often found associated with Pfam:PF01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices [2].
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Ontology Term
PANTHER:PTHR10797 | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT
 
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Ontology Term
Pfam:PF04857 | CAF1 family ribonuclease
Description: The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 Swiss:P39008 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain Pfam:PF01424. This family of proteins is related to other exonucleases Pfam:PF00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 (Swiss:P39008) has been resolved at 2.3 Angstrom resolution [3].
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Ontology Term
PANTHER:PTHR13390 | LIPASE
 
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Ontology Term
PANTHER:PTHR12300 | HVA22-LIKE PROTEINS
 
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Ontology Term
PANTHER:PTHR12300:SF20 | HVA22-LIKE PROTEIN G-RELATED
 
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Ontology Term
Pfam:PF13878 | zinc-finger of acetyl-transferase ESCO
Description: NULL
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Ontology Term
Pfam:PF13880 | ESCO1/2 acetyl-transferase
Description: NULL
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Ontology Term
PANTHER:PTHR13130 | 34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED
 
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Ontology Term
Pfam:PF11571 | Mediator complex subunit 27
Description: Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells [4].
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Ontology Term
PANTHER:PTHR10060 | TATD FAMILY DEOXYRIBONUCLEASE
 
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Ontology Term
Pfam:PF01026 | TatD related DNase
Description: This family of proteins are related to a large superfamily of metalloenzymes [1]. TatD, a member of this family has been shown experimentally to be a DNase enzyme.
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Ontology Term
PANTHER:PTHR31182 | C2 NT-TYPE DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR20941 | FOLATE SYNTHESIS PROTEINS
 
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Ontology Term
Pfam:PF02152 | Dihydroneopterin aldolase
Description: This enzyme EC:4.1.2.25 catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.
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Ontology Term
PANTHER:PTHR32499 | FASCICLIN-LIKE ARABINOGALACTAN PROTEIN 16
 
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Ontology Term
PANTHER:PTHR12972 | DOWNSTREAM NEIGHBOR OF SON
 
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Ontology Term
PANTHER:PTHR11748:SF6 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF07647 | SAM domain (Sterile alpha motif)
Description: NULL
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Ontology Term
PANTHER:PTHR10769 | 40S RIBOSOMAL PROTEIN S28
 
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Ontology Term
Pfam:PF01200 | Ribosomal protein S28e
Description: NULL
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Ontology Term
PANTHER:PTHR10404 | N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE
 
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Ontology Term
Pfam:PF04253 | Transferrin receptor-like dimerisation domain
Description: This domain is involved in dimerisation of the transferrin receptor as shown in its crystal structure.
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Ontology Term
PANTHER:PTHR24619 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR22790 | RHOMBOID-RELATED
 
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Ontology Term
PANTHER:PTHR10131 | TNF RECEPTOR ASSOCIATED FACTOR
 
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Ontology Term
Pfam:PF02176 | TRAF-type zinc finger
Description: NULL
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Ontology Term
PANTHER:PTHR10644:SF1 | SPLICING FACTOR 3B SUBUNIT 3
 
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Ontology Term
PANTHER:PTHR14969 | SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE
 
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Ontology Term
Pfam:PF01569 | PAP2 superfamily
Description: This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.
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Ontology Term
PANTHER:PTHR11199 | STROMAL ANTIGEN
 
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Ontology Term
PANTHER:PTHR11199:SF0 | LD34181P-RELATED
 
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Ontology Term
Pfam:PF08514 | STAG domain
Description: STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organisms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version [1].
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Ontology Term
PANTHER:PTHR12710 | NUCLEAR PROTEIN LOCALIZATION 4
 
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Ontology Term
Pfam:PF05021 | NPL4 family
Description: The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome [1]. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.
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Ontology Term
Pfam:PF11543 | Nuclear pore localisation protein NPL4
Description: Npl4 is part of the heterodimer UN along with Ufd1 which is involved in the recruitment of p97, an AAA ATPase, for tasks involving the ubiquitin pathway. Npl4 has a ubiquitin-like domain which has within its structure a beta-grasp fold with a helical insert [1].
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Ontology Term
PANTHER:PTHR23196:SF1 | LD44171P-RELATED
 
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Ontology Term
Pfam:PF13738 | Pyridine nucleotide-disulphide oxidoreductase
Description: NULL
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Ontology Term
PANTHER:PTHR15657 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR15657:SF1 | THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26
 
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Ontology Term
Pfam:PF08524 | rRNA processing
Description: This is a family of proteins that are involved in rRNA processing [1]. In a localisation study they were found to localise to the nucleus and nucleolus [2]. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1 [3]. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli [4].
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Ontology Term
PANTHER:PTHR31717 | ZINC FINGER PROTEIN CONSTANS-LIKE 10
 
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Ontology Term
PANTHER:PTHR13169 | UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN
 
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Ontology Term
Pfam:PF13881 | Ubiquitin-2 like Rad60 SUMO-like
Description: NULL
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Ontology Term
PANTHER:PTHR10168:SF47 | GLUTAREDOXIN-1-RELATED
 
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Ontology Term
PANTHER:PTHR12419 | OTU DOMAIN CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR12145 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR12145:SF11 | SPERMATOGENESIS-ASSOCIATED PROTEIN 20
 
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Ontology Term
Pfam:PF03190 | Protein of unknown function, DUF255
Description: NULL
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Ontology Term
PANTHER:PTHR10722 | 60S RIBOSOMAL PROTEIN L19
 
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Ontology Term
Pfam:PF01280 | Ribosomal protein L19e
Description: NULL
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Ontology Term
PANTHER:PTHR23077:SF9 | PEROXISOME ASSEMBLY FACTOR 2
 
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Ontology Term
PANTHER:PTHR12506 | PROTEIN PHOSPHATASE RELATED
 
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Ontology Term
PANTHER:PTHR11042 | EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED
 
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Ontology Term
PANTHER:PTHR11227 | WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED
 
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Ontology Term
PANTHER:PTHR11227:SF18 | WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 3
 
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Ontology Term
PANTHER:PTHR10695 | DEPHOSPHO-COA KINASE-RELATED
 
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Ontology Term
Pfam:PF01121 | Dephospho-CoA kinase
Description: This family catalyses the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form Coenzyme A EC:2.7.1.24. This enzyme uses ATP in its reaction.
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Ontology Term
PANTHER:PTHR10025 | TETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE FAMILY MEMBER
 
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Ontology Term
Pfam:PF00763 | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Description: NULL
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Ontology Term
Pfam:PF02882 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Description: NULL
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Ontology Term
Pfam:PF11998 | Low psii accumulation1 / Rep27
Description: This family includes members such as low psii accumulation1 (lpa1) from plants as well as Rep27 proteins found in unicellular green alga Chlamydomonas reinhardtii. The Arabidopsis LPA1 is a chaperone required for efficient photosystem II (PSII) assembly. It binds to psbA during de novo biogenesis of PSII [1]. Other studies show that REP27 in Chlamydomonas reinhardtii chloroplast thylakoids, plays a dual role in the regulation of D1 protein turnover by facilitating cotranslational biosynthesis insertion (C-terminal domain) and activation (tetratricopeptide repeat [TPR] motifs) of the nascent D1 during the PSII repair process [2].
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Ontology Term
PANTHER:PTHR12646 | NOT56 - RELATED
 
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Ontology Term
PANTHER:PTHR12646:SF0 | DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF05208 | ALG3 protein
Description: The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man [3]. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.
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Ontology Term
Pfam:PF04263 | Thiamin pyrophosphokinase, catalytic domain
Description: Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1].
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Ontology Term
Pfam:PF04265 | Thiamin pyrophosphokinase, vitamin B1 binding domain
Description: Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1].
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Ontology Term
PANTHER:PTHR23338:SF16 | U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4
 
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