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Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR31636 | OSJNBA0084A10.13 PROTEIN-RELATED
 
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Ontology Term
Pfam:PF13966 | zinc-binding in reverse transcriptase
Description: This domain would appear to be a zinc-binding region of a putative reverse transcriptase.
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Ontology Term
PANTHER:PTHR14221 | WD REPEAT DOMAIN 44
 
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Ontology Term
PANTHER:PTHR15496 | GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY
 
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Ontology Term
Pfam:PF12657 | Transcription factor IIIC subunit delta N-term
Description: In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts [1]. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8 [2].
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Ontology Term
PANTHER:PTHR11695:SF261 | CINNAMYL ALCOHOL DEHYDROGENASE 2-RELATED
 
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Ontology Term
Pfam:PF08271 | TFIIB zinc-binding
Description: The transcription factor TFIIB contains a zinc-binding motif near the N-terminus. This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site. The domain adopts a zinc ribbon like structure [1].
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Ontology Term
PANTHER:PTHR31414 | TRANSMEMBRANE PROTEIN DDB_G0292058
 
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Ontology Term
PANTHER:PTHR22594 | ASPARTYL/LYSYL-TRNA SYNTHETASE
 
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Ontology Term
PANTHER:PTHR22594:SF4 | LYSINE--TRNA LIGASE
 
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Ontology Term
Pfam:PF01336 | OB-fold nucleic acid binding domain
Description: This family contains OB-fold domains that bind to nucleic acids [4]. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See Pfam:PF00152). Aminoacyl-tRNA synthetases catalyse the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family [2,3]. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
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Ontology Term
Pfam:PF01794 | Ferric reductase like transmembrane component
Description: This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane [1]. The Frp1 protein Swiss:Q04800 from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake [1]. Cytochrome B-245 heavy chain Swiss:P04839 is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants [2]. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterised by the absence of a functional plasma membrane associated NADPH oxidase [3]. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease [4].
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Ontology Term
Pfam:PF08030 | Ferric reductase NAD binding domain
Description: NULL
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Ontology Term
PANTHER:PTHR24326:SF67 | HOMEOBOX-LEUCINE ZIPPER FAMILY PROTEIN-RELATED
 
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Ontology Term
Pfam:PF00046 | Homeodomain
Description: NULL
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Ontology Term
Pfam:PF00312 | Ribosomal protein S15
Description: NULL
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Ontology Term
Pfam:PF05758 | Ycf1
Description: The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. Although the function of Ycf1 is unknown, it is known to be an essential gene [1].
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Ontology Term
PANTHER:PTHR12989 | ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10
 
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Ontology Term
Pfam:PF04922 | DIE2/ALG10 family
Description: The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterised in rat as potassium channel regulator 1 [2].
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Ontology Term
PANTHER:PTHR21562 | NOTUM-RELATED
 
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Ontology Term
Pfam:PF03283 | Pectinacetylesterase
Description: NULL
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Ontology Term
PANTHER:PTHR11528 | HEAT SHOCK PROTEIN 90 FAMILY MEMBER
 
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Ontology Term
Pfam:PF00183 | Hsp90 protein
Description: NULL
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Ontology Term
PANTHER:PTHR13832 | PROTEIN PHOSPHATASE 2C
 
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Ontology Term
PANTHER:PTHR13832:SF102 | PROTEIN PHOSPHATASE 1L
 
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Ontology Term
Pfam:PF00481 | Protein phosphatase 2C
Description: Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.
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Ontology Term
Pfam:PF01439 | Metallothionein
Description: Members of this family are metallothioneins. These proteins are cysteine rich proteins that bind to heavy metals. Members of this family appear to be closest to Class II metallothioneins, seed Pfam:PF00131.
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Ontology Term
Pfam:PF12836 | Helix-hairpin-helix motif
Description: The HhH domain is a short DNA-binding domain [2].
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Ontology Term
PANTHER:PTHR13078 | PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED
 
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Ontology Term
Pfam:PF01575 | MaoC like domain
Description: The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.
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Ontology Term
PANTHER:PTHR10641:SF221 | MYB PROTEIN
 
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Ontology Term
Pfam:PF13921 | Myb-like DNA-binding domain
Description: This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].
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Ontology Term
PANTHER:PTHR21497 | UBIQUITIN LIGASE E3 ALPHA-RELATED
 
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Ontology Term
Pfam:PF02207 | Putative zinc finger in N-recognin (UBR box)
Description: This region is found in E3 ubiquitin ligases that recognise N-recognins [1].
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Ontology Term
PANTHER:PTHR31867 | EXPANSIN-A15
 
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Ontology Term
Pfam:PF01357 | Expansin C-terminal domain
Description: This domain is found at the C-terminus of expansins, plant cell wall proteins involved in the non-enzymatic rearrangement of cell walls during cell growth. It contains the allergens lol PI, PII and PIII from Lolium perenne.
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Ontology Term
Pfam:PF03330 | Lytic transglycolase
Description: Rare lipoprotein A (RlpA) contains a conserved region that has the double-psi beta-barrel (DPBB) fold [3,4]. The function of RlpA is not well understood, but it has been shown to act as a prc mutant suppressor in Escherichia coli [1]. The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions. Another example of this domain is found in the N terminus of pollen allergen. Recent studies show that the full-length RlpA protein from Pseudomonas Aeruginosa is an outer membrane protein that is a lytic transglycolase with specificity for peptidoglycan lacking stem peptides. Residue D157 in UniProtKB:Q9X6V6 is critical for lytic activity [5].
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Ontology Term
PANTHER:PTHR31218 | WAT1-RELATED PROTEIN
 
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Ontology Term
Pfam:PF00892 | EamA-like transporter family
Description: This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.
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Ontology Term
PANTHER:PTHR22936 | RHOMBOID-RELATED
 
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Ontology Term
Pfam:PF01694 | Rhomboid family
Description: This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease [2][3][4] (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite [5].
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Ontology Term
PANTHER:PTHR10972 | OXYSTEROL-BINDING PROTEIN-RELATED
 
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Ontology Term
Pfam:PF01237 | Oxysterol-binding protein
Description: NULL
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Ontology Term
PANTHER:PTHR10775 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR24128 | HOMEOBOX PROTEIN WARIAI
 
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Ontology Term
Pfam:PF13606 | Ankyrin repeat
Description: Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
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Ontology Term
Pfam:PF03643 | Vacuolar protein sorting-associated protein 26
Description: Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking. In particular, Vps26 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35 [1]. This family also contains Down syndrome critical region 3/A.
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Ontology Term
PANTHER:PTHR31140:SF1 | AP2/ERF AND B3 DOMAIN-CONTAINING TRANSCRIPTION REPRESSOR RAV2
 
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Ontology Term
Pfam:PF05970 | PIF1-like helicase
Description: This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated [1][2]. This family includes a large number of largely uncharacterised plant proteins. This family includes a P-loop motif that is involved in nucleotide binding.
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Ontology Term
PANTHER:PTHR13520 | RAD50-INTERACTING PROTEIN 1 RINT-1
 
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Ontology Term
Pfam:PF04437 | RINT-1 / TIP-1 family
Description: This family includes RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control [1], as well as the TIP-1 protein from yeast that seems to be involved in a complex with Sec20p that is required for Golgi transport [2].
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Ontology Term
Pfam:PF02992 | Transposase family tnp2
Description: Transposase_21 proteins are present mostly in plants, with members horizontally transferred to Bifidobacterium breve (GI: 291457831). Both DUF1258 Pfam:PF06869 and Transposase_21 have conserved active site residues similar to RNase H-like proteins, which suggests that they are functional transposases (1).
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Ontology Term
Pfam:PF13960 | Domain of unknown function (DUF4218)
Description: NULL
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Ontology Term
PANTHER:PTHR31683 | PECTATE LYASE 18-RELATED
 
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Ontology Term
Pfam:PF00544 | Pectate lyase
Description: This enzyme forms a right handed beta helix structure. Pectate lyase is an enzyme involved in the maceration and soft rotting of plant tissue.
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Ontology Term
PANTHER:PTHR22904 | TPR REPEAT CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR22904:SF71 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF07719 | Tetratricopeptide repeat
Description: This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by Pfam:PF00515.
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Ontology Term
PANTHER:PTHR19241 | ATP-BINDING CASSETTE TRANSPORTER
 
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Ontology Term
Pfam:PF01061 | ABC-2 type transporter
Description: NULL
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Ontology Term
PANTHER:PTHR11937 | ACTIN
 
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Ontology Term
Pfam:PF00022 | Actin
Description: NULL
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Ontology Term
Pfam:PF08646 | Replication factor-A C terminal domain
Description: This domain is found at the C terminal of replication factor A. Replication factor A (RPA) binds single-stranded DNA and is involved in replication, repair, and recombination of DNA [1].
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Ontology Term
Pfam:PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase)
Description: A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
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Ontology Term
PANTHER:PTHR23089 | HISTIDINE TRIAD HIT PROTEIN
 
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Ontology Term
Pfam:PF01230 | HIT domain
Description: NULL
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Ontology Term
PANTHER:PTHR23355 | RIBONUCLEASE
 
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Ontology Term
PANTHER:PTHR23355:SF5 | EXORIBONUCLEASE II, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00773 | RNB domain
Description: This domain is the catalytic domain of ribonuclease II [1].
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Ontology Term
PANTHER:PTHR10693 | RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN
 
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Ontology Term
Pfam:PF02136 | Nuclear transport factor 2 (NTF2) domain
Description: This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.
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Ontology Term
PANTHER:PTHR32116 | GALACTURONOSYLTRANSFERASE 4-RELATED
 
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Ontology Term
PANTHER:PTHR24420:SF430 | PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK12-RELATED
 
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Ontology Term
PANTHER:PTHR18934 | ATP-DEPENDENT RNA HELICASE
 
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Ontology Term
Pfam:PF04408 | Helicase associated domain (HA2)
Description: This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
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Ontology Term
Pfam:PF07717 | Oligonucleotide/oligosaccharide-binding (OB)-fold
Description: This family is found towards the C-terminus of the DEAD-box helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. There do seem to be a couple of instances where it occurs by itself - e.g. Swiss:Q84VZ2. The structure PDB:3i4u adopts an OB-fold. helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins [1].
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Ontology Term
PANTHER:PTHR32467 | AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR
 
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Ontology Term
Pfam:PF08186 | Wound-inducible basic protein family
Description: This family consists of the wound-inducible basic proteins from plants. The metabolic activities of plants are dramatically altered upon mechanical injury or pathogen attack. A large number of proteins accumulates at wound or infection sites, such as the wound-inducible basic proteins. These proteins are small, 47 amino acids in length, has no signal peptides and are hydrophilic and basic [1].
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Ontology Term
PANTHER:PTHR12947 | AMSH-LIKE PROTEASE
 
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Ontology Term
PANTHER:PTHR12947:SF4 | REGULATOR OF FREE UBIQUITIN CHAINS 1
 
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Ontology Term
PANTHER:PTHR10031 | ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00137 | ATP synthase subunit C
Description: NULL
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Ontology Term
PANTHER:PTHR12701 | BCR-ASSOCIATED PROTEIN, BAP
 
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Ontology Term
Pfam:PF05266 | Protein of unknown function (DUF724)
Description: This family contains several uncharacterised proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.
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Ontology Term
Pfam:PF05529 | Bap31/Bap29 transmembrane region
Description: Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31 [1]. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.
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Ontology Term
Pfam:PF05627 | Cleavage site for pathogenic type III effector avirulence factor Avr
Description: This domain is conserved in small families of otherwise unrelated proteins in both mono-cots and di-cots, suggesting that it has a conserved, plant-specific function. It is found both in the plant RIN4 (resistance R membrane-bound host-target protein) where it appears to contribute to the binding of the protein to both RCS (AvrRpt2 auto-cleavage site) and AvrB, the virulence factor from the infecting bacterium [1]. The cleavage site for the AvrRpt2 avirulence protein would appear to be the sequence motifs VPQFGDW and LPKFGEW, both of which are highly conserved within the domain [3].
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Ontology Term
PANTHER:PTHR31727 | OLEOYL-ACYL CARRIER PROTEIN THIOESTERASE 1, CHLOROPLASTIC
 
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Ontology Term
PANTHER:PTHR31727:SF0 | OLEOYL-ACYL CARRIER PROTEIN THIOESTERASE 1, CHLOROPLASTIC-RELATED
 
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Ontology Term
Pfam:PF01643 | Acyl-ACP thioesterase
Description: This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid [1].
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Ontology Term
PANTHER:PTHR21712 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF00498 | FHA domain
Description: The FHA (Forkhead-associated) domain is a phosphopeptide binding motif [2].
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Ontology Term
Pfam:PF07727 | Reverse transcriptase (RNA-dependent DNA polymerase)
Description: A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses. This Pfam entry includes reverse transcriptases not recognised by the Pfam:PF00078 model.
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Ontology Term
Pfam:PF13976 | GAG-pre-integrase domain
Description: This domain is found associated with retroviral insertion elements and lies just upstream of the integrase region on the polyproteins.
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Ontology Term
Pfam:PF14223 | gag-polypeptide of LTR copia-type
Description: This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.
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Ontology Term
PANTHER:PTHR32021 | CASP-LIKE PROTEIN 5B3
 
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Ontology Term
PANTHER:PTHR32021:SF0 | CASP-LIKE PROTEIN 5B2
 
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Ontology Term
Pfam:PF04535 | Casparian strip membrane protein domain
Description: This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs) and CASP-like proteins (CASPLs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking Casparian strips [1,2].
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Ontology Term
PANTHER:PTHR13561 | DNA REPLICATION REGULATOR DPB11-RELATED
 
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Ontology Term
Pfam:PF12738 | twin BRCT domain
Description: This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair [1,2].
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Ontology Term
PANTHER:PTHR19446 | REVERSE TRANSCRIPTASES
 
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