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Search results 4501 to 4600 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR11134:SF4 | AP-4 COMPLEX SUBUNIT BETA-1
 
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Ontology Term
PANTHER:PTHR12174:SF23 | MINOR HISTOCOMPATIBILITY ANTIGEN H13
 
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Ontology Term
PANTHER:PTHR13049 | DUF814-RELATED
 
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Ontology Term
Pfam:PF05670 | NFACT protein RNA binding domain
Description: This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity [1]. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain [2]. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.
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Ontology Term
PANTHER:PTHR13242 | EUKARYOTIC TRANSLATION INITIATION FACTOR 3
 
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Ontology Term
Pfam:PF10255 | RNA polymerase I-associated factor PAF67
Description: RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67 [1]. This family of proteins is conserved from worms to humans.
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Ontology Term
PANTHER:PTHR24067:SF56 | NEDD8-CONJUGATING ENZYME UBE2F-RELATED
 
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Ontology Term
PANTHER:PTHR17630 | DIENELACTONE HYDROLASE
 
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Ontology Term
PANTHER:PTHR21573 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR21573:SF0 | ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1
 
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Ontology Term
Pfam:PF07774 | ER membrane protein complex subunit 1, C-terminal
Description: This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) [1].
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Ontology Term
Pfam:PF13360 | PQQ-like domain
Description: This domain contains several repeats of the PQQ repeat.
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Ontology Term
Pfam:PF14249 | Tocopherol cyclase
Description: This family contains tocopherol cyclases. These enzymes are involved in the synthesis of tocopherols and tocotrienols (vitamin E) [1].
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Ontology Term
PANTHER:PTHR10984 | ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN
 
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Ontology Term
PANTHER:PTHR10984:SF2 | ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 1
 
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Ontology Term
Pfam:PF13850 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
Description: This family is the N-terminal of ERGIC proteins [1], ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, Pfam:PF07970.
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Ontology Term
PANTHER:PTHR19139:SF51 | AQUAPORIN TIP4-1
 
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Ontology Term
PANTHER:PTHR10543:SF6 | 15,15' BETA CAROTENE DIOXYGENASE
 
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Ontology Term
PANTHER:PTHR12532 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR12532:SF0 | TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1
 
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Ontology Term
Pfam:PF01709 | Transcriptional regulator
Description: This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1 [2]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3].
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Ontology Term
Pfam:PF13540 | Regulator of chromosome condensation (RCC1) repeat
Description: NULL
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Ontology Term
PANTHER:PTHR10682 | POLY A POLYMERASE
 
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Ontology Term
Pfam:PF04926 | Poly(A) polymerase predicted RNA binding domain
Description: Based on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding [1].
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Ontology Term
Pfam:PF04928 | Poly(A) polymerase central domain
Description: The central domain of Poly(A) polymerase shares structural similarity with the allosteric activity domain of ribonucleotide reductase R1, which comprises a four-helix bundle and a three-stranded mixed beta- sheet. Even though the two enzymes bind ATP, the ATP-recognition motifs are different.
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Ontology Term
PANTHER:PTHR15451 | ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED
 
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Ontology Term
Pfam:PF03694 | Erg28 like protein
Description: This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins [1]. The family contains a conserved arginine and histidine that may be functionally important.
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Ontology Term
Pfam:PF05770 | Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain
Description: This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1]. This entry represents the ATP-grasp domain.
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Ontology Term
PANTHER:PTHR10196 | SUGAR KINASE
 
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Ontology Term
PANTHER:PTHR10196:SF10 | FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF00370 | FGGY family of carbohydrate kinases, N-terminal domain
Description: This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.
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Ontology Term
Pfam:PF02782 | FGGY family of carbohydrate kinases, C-terminal domain
Description: This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.
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Ontology Term
PANTHER:PTHR19432 | SUGAR TRANSPORTER
 
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Ontology Term
Pfam:PF13347 | MFS/sugar transport protein
Description: This family is part of the major facilitator superfamily of membrane transport proteins.
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Ontology Term
PANTHER:PTHR12921 | UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1
 
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Ontology Term
Pfam:PF08694 | Ubiquitin-fold modifier-conjugating enzyme 1
Description: Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1 is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family represents the E2-like enzyme.
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Ontology Term
PANTHER:PTHR30031 | PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP
 
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Ontology Term
PANTHER:PTHR30031:SF0 | PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)
 
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Ontology Term
Pfam:PF01293 | Phosphoenolpyruvate carboxykinase
Description: NULL
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Ontology Term
PANTHER:PTHR10579 | CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR
 
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Ontology Term
Pfam:PF00092 | von Willebrand factor type A domain
Description: NULL
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Ontology Term
Pfam:PF14778 | Odorant response abnormal 4-like
Description: In C.elegans, odr-4 and odr-8 are required for localising a subset of odorant GPCRs to the cilia of olfactory neurons [1]. Olfactory receptors (ORs) are synthesised in endoplasmic reticulum of the olfactory neurons, trafficked to the cell surface membrane and transported to the tip of the olfactory cilium, where they bind with odorants. Various accessory proteins are required for proper targetting of different ORs to the cell membrane. ODR-4 was the first accessory protein to be described.
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Ontology Term
PANTHER:PTHR16295 | TRAF-TYPE ZINC FINGER PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR23176 | RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN
 
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Ontology Term
PANTHER:PTHR23419 | DIVALENT CATION TOLERANCE CUTA-RELATED
 
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Ontology Term
Pfam:PF03091 | CutA1 divalent ion tolerance protein
Description: Several gene loci with a possible involvement in cellular tolerance to copper have been identified [1]. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognised structural motifs [2]. This family also contains putative proteins from eukaryotes (human and Drosophila).
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Ontology Term
PANTHER:PTHR15574 | WD REPEAT DOMAIN-CONTAINING FAMILY
 
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Ontology Term
PANTHER:PTHR15574:SF21 | DDB1 AND CUL4-ASSOCIATED FACTOR 8
 
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Ontology Term
PANTHER:PTHR23125:SF100 | F-BOX PROTEIN FBX14-RELATED
 
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Ontology Term
PANTHER:PTHR10851 | PYRIDOXINE-5-PHOSPHATE OXIDASE
 
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Ontology Term
PANTHER:PTHR10851:SF0 | PYRIDOXINE-5'-PHOSPHATE OXIDASE
 
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Ontology Term
Pfam:PF10590 | Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
Description: This domain represents one of the two dimerisation regions of the protein, located at the edge of the dimer interface, at the C-terminus, being the last three beta strands, S6, S7, and S8 along with the last three residues to the end. In Swiss:P21159, S6 runs from residues 178-192, S7 from 200-206 and S8 from 211-215. the extended loop, of residues 167-177 may well be involved in the pocket formed between the two dimers that positions the FMN molecule [1].To date, the only time functional oxidase or phenazine biosynthesis activities have been experimentally demonstrated is when the sequences contain both Pfam:PF01243 and Pfam:PF10590. It is unknown the role performed by each domain in bringing about molecular functions of either oxidase or phenazine activity [2].
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Ontology Term
PANTHER:PTHR13232 | NAD(P)H-HYDRATE EPIMERASE
 
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Ontology Term
Pfam:PF03853 | YjeF-related protein N-terminus
Description: YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases [1]. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128) [1], where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions [1].
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Ontology Term
PANTHER:PTHR12438 | UBIQUITIN-LIKE PROTEASE PROTEIN 2
 
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Ontology Term
PANTHER:PTHR12438:SF7 | THIOL PROTEASE ULP-4-RELATED
 
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Ontology Term
PANTHER:PTHR31933 | O-FUCOSYLTRANSFERASE 2-RELATED
 
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Ontology Term
PANTHER:PTHR30566 | YNAI-RELATED MECHANOSENSITIVE ION CHANNEL
 
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Ontology Term
PANTHER:PTHR10048:SF7 | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
 
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Ontology Term
Pfam:PF00792 | Phosphoinositide 3-kinase C2
Description: Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family.
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Ontology Term
PANTHER:PTHR11444 | ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE
 
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Ontology Term
PANTHER:PTHR11444:SF3 | ARGININOSUCCINATE LYASE
 
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Ontology Term
Pfam:PF00206 | Lyase
Description: NULL
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Ontology Term
Pfam:PF14698 | Argininosuccinate lyase C-terminal
Description: This domain is found at the C-terminus of argininosuccinate lyase [1-2].
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Ontology Term
PANTHER:PTHR31631 | PROTEIN NETWORKED 2D
 
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Ontology Term
PANTHER:PTHR31631:SF0 | PROTEIN NETWORKED 2D
 
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Ontology Term
PANTHER:PTHR11129:SF2 | GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA
 
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Ontology Term
PANTHER:PTHR19384 | NITRIC OXIDE SYNTHASE-RELATED
 
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Ontology Term
Pfam:PF00258 | Flavodoxin
Description: NULL
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Ontology Term
Pfam:PF00667 | FAD binding domain
Description: This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.
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Ontology Term
PANTHER:PTHR13743 | BEIGE/BEACH-RELATED
 
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Ontology Term
PANTHER:PTHR13743:SF16 | BEIGE PROTEIN HOMOLOG 1
 
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Ontology Term
Pfam:PF02138 | Beige/BEACH domain
Description: NULL
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Ontology Term
Pfam:PF13385 | Concanavalin A-like lectin/glucanases superfamily
Description: This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.
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Ontology Term
Pfam:PF14844 | PH domain associated with Beige/BEACH
Description: This PH domain is found in proteins containing the Beige/BEACH domain (Pfam:PF02138), it immediately precedes the Beige/BEACH domain [1].
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Ontology Term
PANTHER:PTHR15678 | ANTIGEN MLAA-22-RELATED
 
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Ontology Term
PANTHER:PTHR15678:SF6 | PROTEIN KIAA0100
 
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Ontology Term
Pfam:PF10351 | Golgi-body localisation protein domain
Description: This is the C-terminus of a family of proteins conserved from plants to humans. The plant members are localised to the Golgi proteins and appear to regulate membrane trafficking, as they are required for rapid vesicle accumulation at the tip of the pollen tube [1]. The C-terminus probably contains the Golgi localisation signal and it is well-conserved.
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Ontology Term
Pfam:PF10347 | RNA pol II promoter Fmp27 protein domain
Description: Fmp27_GFWDK is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic GFWDK sequence motifs. Some members are associated with domain Fmp27_SW (Pfam:PF10305) towards the N terminus.
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Ontology Term
PANTHER:PTHR13237 | SOMETHING ABOUT SILENCING PROTEIN 10-RELATED
 
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Ontology Term
Pfam:PF04000 | Sas10/Utp3/C1D family
Description: This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex [2][4]. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs [3], and Sas10 which has been identified as a regulator of chromatin silencing [1]. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein [6].
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Ontology Term
PANTHER:PTHR31326 | PROTEIN CLT2, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF08627 | CRT-like, chloroquine-resistance transporter-like
Description: This family represents the Plasmodium falciparum chloroquine resistance transporter (CRT) and homologous proteins. CRT regulates other transporters, like Na-H antiporter or nonselective cation transporters [1]. The Arabidopsis homologues are involved in thiol transport from the plastid to the cytosol, playing a significant role in regulating GSH levels and the redox potential of the cytosol [2]. Homologues from Dictyostelium discoideum are also included in this family [3].
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Ontology Term
PANTHER:PTHR24011:SF95 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF09809 | Mitochondrial ribosomal protein L27
Description: Members of this family of proteins are components of the mitochondrial ribosome large subunit. They are also involved in apoptosis and cell cycle regulation.
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Ontology Term
PANTHER:PTHR11778 | SERYL-TRNA SYNTHETASE
 
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Ontology Term
PANTHER:PTHR11778:SF0 | SERINE--TRNA LIGASE, CYTOPLASMIC
 
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Ontology Term
Pfam:PF02403 | Seryl-tRNA synthetase N-terminal domain
Description: This domain is found associated with the Pfam tRNA synthetase class II domain (Pfam:PF00587) and represents the N-terminal domain of seryl-tRNA synthetase.
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Ontology Term
PANTHER:PTHR12480 | ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD
 
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Ontology Term
PANTHER:PTHR12480:SF12 | JMJC DOMAIN-CONTAINING PROTEIN 8
 
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Ontology Term
PANTHER:PTHR10588 | LEUCINE-RICH REPEAT-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF12546 | Blue/Ultraviolet sensing protein C terminal
Description: This domain family is found in eukaryotes, and is typically between 113 and 125 amino acids in length. The family is found in association with Pfam:PF03441, Pfam:PF00875. Cryptochromes are blue/ultraviolet-A light sensing photoreceptors involved in regulating various growth and developmental responses in plants.
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Ontology Term
PANTHER:PTHR24305 | CYTOCHROME P450
 
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Ontology Term
PANTHER:PTHR13395 | SISTER CHROMATID COHESION PROTEIN DCC1-RELATED
 
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Ontology Term
Pfam:PF09724 | Sister chromatid cohesion protein Dcc1
Description: Sister chromatid cohesion protein Dcc1 is a component of the Ctf18-RFC complex. This complex is required for the efficient establishment of chromosome cohesion during S-phase and for loading the replication clamp Pol30/PCNA, which functions in DNA replication and repair [1,2]. Ctf18-RFC loads PCNA onto DNA in an ATP-dependent manner. It may also have PCNA-unloading activity [3].
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Ontology Term
PANTHER:PTHR13165 | ARSENITE-RESISTANCE PROTEIN 2
 
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Ontology Term
Pfam:PF04959 | Arsenite-resistance protein 2
Description: Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance [1].
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Ontology Term
Pfam:PF12066 | SERRATE/Ars2, N-terminal domain
Description: This domain can be found in the N terminus of the SERRATE (SE) from plants and its homologue, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe [1]. This domain has two completely conserved Y residues that may be functionally important.
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Ontology Term
PANTHER:PTHR10615 | HISTONE ACETYLTRANSFERASE
 
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Ontology Term
Pfam:PF01853 | MOZ/SAS family
Description: This region of these proteins has been suggested to be homologous to acetyltransferases [1].
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