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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF02245 | Methylpurine-DNA glycosylase (MPG)
Description: Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.
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Ontology Term
PANTHER:PTHR19302:SF14 | GAMMA-TUBULIN COMPLEX COMPONENT 3
 
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Ontology Term
PANTHER:PTHR21495:SF15 | DISEASE RESISTANCE-RESPONSIVE (DIRIGENT-LIKE PROTEIN) FAMILY PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR13268 | BREAST CARCINOMA AMPLIFIED SEQUENCE 3
 
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Ontology Term
PANTHER:PTHR13268:SF0 | BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR
 
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Ontology Term
Pfam:PF12490 | Breast carcinoma amplified sequence 3
Description: This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.
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Ontology Term
PANTHER:PTHR16019 | SYNAPSE-ASSOCIATED PROTEIN
 
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Ontology Term
Pfam:PF00917 | MATH domain
Description: This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans [3].
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Ontology Term
PANTHER:PTHR13018 | PROBABLE MEMBRANE PROTEIN DUF221-RELATED
 
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Ontology Term
PANTHER:PTHR13018:SF5 | RE44586P
 
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Ontology Term
Pfam:PF02714 | Calcium-dependent channel, 7TM region, putative phosphate
Description: RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter [1,2]. The family is the 7TM region of osmosensitive calcium-permeable cation channels [3].
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Ontology Term
Pfam:PF13967 | Late exocytosis, associated with Golgi transport
Description: This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localised to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface [1].
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Ontology Term
PANTHER:PTHR12550 | HEPATOMA-DERIVED GROWTH FACTOR-RELATED
 
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Ontology Term
PANTHER:PTHR12550:SF5 | HUA2-LIKE PROTEIN 2-RELATED
 
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Ontology Term
PANTHER:PTHR11088 | TRNA DIMETHYLALLYLTRANSFERASE
 
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Ontology Term
Pfam:PF01715 | IPP transferase
Description: This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37) [2].
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Ontology Term
PANTHER:PTHR23338 | SMALL NUCLEAR RIBONUCLEOPROTEIN SM
 
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Ontology Term
PANTHER:PTHR23338:SF18 | SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1
 
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Ontology Term
PANTHER:PTHR11514:SF9 | TRANSCRIPTION FACTOR EGL1-RELATED
 
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Ontology Term
PANTHER:PTHR10906 | SECY/SEC61-ALPHA FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR10906:SF2 | PREPROTEIN TRANSLOCASE SUBUNIT SCY2, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF00344 | SecY
Description: NULL
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Ontology Term
PANTHER:PTHR24072:SF73 | MITOCHONDRIAL RHO GTPASE
 
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Ontology Term
Pfam:PF08356 | EF hand associated
Description: This region predominantly appears near EF-hands (Pfam:PF00036) in GTP-binding proteins. It is found in all three eukaryotic kingdoms.
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Ontology Term
Pfam:PF08477 | Ras of Complex, Roc, domain of DAPkinase
Description: Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, Swiss:Q8IXI2, and Miro-2, Swiss:Q8IXI1) and atypical Rho GTPases. Full-length proteins have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (Pfam:PF00036) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis [1,2,3,4].
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Ontology Term
Pfam:PF08355 | EF hand associated
Description: This region typically appears on the C-terminus of EF hands in GTP-binding proteins such as Arht/Rhot (may be involved in mitochondrial homeostasis and apoptosis[1]). The EF hand associated region is found in yeast, vertebrates and plants.
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Ontology Term
PANTHER:PTHR31016 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR32241 | PATATIN-LIKE PROTEIN 6
 
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Ontology Term
PANTHER:PTHR31739 | ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF02431 | Chalcone-flavanone isomerase
Description: Chalcone-flavanone isomerase is a plant enzyme responsible for the isomerisation of chalcone to naringenin, 4',5,7-trihydroxyflavanone, a key step in the biosynthesis of flavonoids.
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Ontology Term
PANTHER:PTHR13007 | PRE-MRNA SPLICING FACTOR-RELATED
 
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Ontology Term
Pfam:PF02840 | Prp18 domain
Description: The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known [1]. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles [1].
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Ontology Term
Pfam:PF08799 | pre-mRNA processing factor 4 (PRP4) like
Description: This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.
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Ontology Term
PANTHER:PTHR16288 | WD40 REPEAT PROTEIN 4
 
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Ontology Term
PANTHER:PTHR16288:SF0 | TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4
 
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Ontology Term
PANTHER:PTHR24414:SF14 | F-BOX PROTEIN AFR-RELATED
 
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Ontology Term
PANTHER:PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED
 
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Ontology Term
PANTHER:PTHR21091:SF6 | HOMOCYSTEINE S-METHYLTRANSFERASE 3
 
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Ontology Term
Pfam:PF02574 | Homocysteine S-methyltransferase
Description: This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13, [2]; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5, [3]; and Homocysteine S-methyltransferase, EC:2.1.1.10, [1].
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Ontology Term
PANTHER:PTHR22811:SF31 | TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN P24BETA3
 
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Ontology Term
Pfam:PF13225 | Beta-carotene isomerase D27-like, C-terminal
Description: This is the C-terminal domain of Beta-carotene isomerase D27 that may contain an iron binding domain [1]. Beta-carotene isomerase D27 (also known as Protein DWARF-27) from plants is involved in strigolactones biosynthesis. It is a beta-carotene isomerase that converts all-trans-beta-carotene into 9-cis-beta-carotene, which is cleaved by CCD7 into a 9-cis-configured aldehyde [2,3]. This is an iron-containing protein that localises in chloroplasts and is expressed mainly in vascular cells of shoots and roots [1].
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Ontology Term
PANTHER:PTHR10314:SF4 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF00290 | Tryptophan synthase alpha chain
Description: NULL
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Ontology Term
PANTHER:PTHR16223 | TRANSCRIPTION FACTOR BHLH83-RELATED
 
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Ontology Term
PANTHER:PTHR23125:SF166 | F-BOX/LRR-REPEAT PROTEIN 17
 
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Ontology Term
Pfam:PF07123 | Photosystem II reaction centre W protein (PsbW)
Description: This family consists of several plant specific photosystem II reaction centre W (PsbW) proteins. PsbW is a nuclear-encoded protein located in the thylakoid membrane of the chloroplast. PsbW is a core component of photosystem II but not photosystem I [1]. This family does not appear to be related to Pfam:PF03912.
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Ontology Term
PANTHER:PTHR32116:SF0 | GALACTURONOSYLTRANSFERASE 6-RELATED
 
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Ontology Term
PANTHER:PTHR31153 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR12791 | GOLGI SNARE BET1-RELATED
 
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Ontology Term
PANTHER:PTHR12791:SF5 | BET1-LIKE SNARE 1-1-RELATED
 
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Ontology Term
PANTHER:PTHR12697 | PBS LYASE HEAT-LIKE PROTEIN
 
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Ontology Term
Pfam:PF03130 | PBS lyase HEAT-like repeat
Description: This family contains a short bi-helical repeat that is related to Pfam:PF02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase Swiss:P31967 Swiss:P31968, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin [1]. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six) [2]. All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond. Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerised to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerisation reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase [3]. Another member of this family is the NblB protein Swiss:Q9Z3G5, whose similarity to the phycobiliprotein lyases was previously noted [4]. This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif [4].
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Ontology Term
PANTHER:PTHR24015:SF166 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR15447 | POLY [ADP-RIBOSE] POLYMERASE
 
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Ontology Term
Pfam:PF00644 | Poly(ADP-ribose) polymerase catalytic domain
Description: Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active [2].
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Ontology Term
Pfam:PF00645 | Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Description: Poly(ADP-ribose) polymerase is an important regulatory component of the cellular response to DNA damage. The amino-terminal region of Poly(ADP-ribose) polymerase consists of two PARP-type zinc fingers. This region acts as a DNA nick sensor.
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Ontology Term
Pfam:PF02877 | Poly(ADP-ribose) polymerase, regulatory domain
Description: Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active [2].
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Ontology Term
Pfam:PF05406 | WGR domain
Description: This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Swiss:Q9JN21 and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain.
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Ontology Term
Pfam:PF08063 | PADR1 (NUC008) domain
Description: This domain is found in poly(ADP-ribose)-synthetases [1]. The function of this domain is unknown.
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Ontology Term
PANTHER:PTHR31474 | HR-LIKE LESION-INDUCER
 
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Ontology Term
Pfam:PF05514 | HR-like lesion-inducing
Description: Family of plant proteins that are associated with the hypersensitive response (HR) pathway of defence against plant pathogens.
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Ontology Term
PANTHER:PTHR13038 | APG9 AUTOPHAGY 9
 
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Ontology Term
PANTHER:PTHR13038:SF10 | AUTOPHAGY-RELATED PROTEIN 9
 
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Ontology Term
Pfam:PF04109 | Autophagy protein ATG9
Description: In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells [1,2]. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalises with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes [2,3]. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion [3].
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Ontology Term
PANTHER:PTHR24064 | SOLUTE CARRIER FAMILY 22 MEMBER
 
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Ontology Term
PANTHER:PTHR11913:SF12 | COFILIN/ACTIN-DEPOLYMERIZING FACTOR HOMOLOG-RELATED
 
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Ontology Term
PANTHER:PTHR12770:SF5 | PROTEIN ROOT UVB SENSITIVE 2, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF05023 | Phytochelatin synthase
Description: Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols [2]. The crystal structure of a member of this family shows it to possess a papain fold [3]. The enzyme catalyses the deglycination of a GSH donor molecule [3]. The enzyme contains a catalytic triad of cysteine, histidine and aspartate residues.
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Ontology Term
Pfam:PF09328 | Domain of unknown function (DUF1984)
Description: Members of this family of functionally uncharacterised domains are found at the C-terminus of plant phytochelatin synthases.
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Ontology Term
PANTHER:PTHR11440 | LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED
 
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Ontology Term
PANTHER:PTHR11440:SF7 | PHOSPHOLIPID--STEROL O-ACYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR13763 | BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1
 
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Ontology Term
PANTHER:PTHR13763:SF0 | BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN
 
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Ontology Term
PANTHER:PTHR13021 | PRE-MRNA-SPLICING FACTOR ISY1
 
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Ontology Term
Pfam:PF06246 | Isy1-like splicing family
Description: Isy1 protein is important in the optimisation of splicing [1].
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Ontology Term
PANTHER:PTHR31284 | ACID PHOSPHATASE-LIKE PROTEIN
 
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Ontology Term
Pfam:PF03767 | HAD superfamily, subfamily IIIB (Acid phosphatase)
Description: This family proteins includes acid phosphatases and a number of vegetative storage proteins.
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Ontology Term
Pfam:PF08695 | Cytochrome oxidase complex assembly protein 1
Description: Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence [1]. The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex [2].
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Ontology Term
PANTHER:PTHR16017 | GASTRULATION DEFECTIVE PROTEIN 1-RELATED
 
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Ontology Term
PANTHER:PTHR16017:SF0 | WD REPEAT-CONTAINING PROTEIN 70
 
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Ontology Term
Pfam:PF10280 | Mediator complex protein
Description: Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organisation is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans [2]. Med11 appears to be necessary for the full and successful assembly of the core head sub-region [4].
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Ontology Term
Pfam:PF05899 | EutQ-like cupin domain
Description: This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerisation found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity [1]. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins [2]. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilisation via the assimilation of allantoin. It catalyses the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine [3,4].
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Ontology Term
PANTHER:PTHR22874 | ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1
 
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Ontology Term
PANTHER:PTHR22874:SF1 | ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1
 
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Ontology Term
PANTHER:PTHR22838 | WD REPEAT PROTEIN 26-RELATED
 
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Ontology Term
PANTHER:PTHR22838:SF0 | WD REPEAT-CONTAINING PROTEIN 26
 
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Ontology Term
PANTHER:PTHR10584:SF104 | PFKB-LIKE CARBOHYDRATE KINASE FAMILY PROTEIN
 
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Ontology Term
Pfam:PF02736 | Myosin N-terminal SH3-like domain
Description: This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
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Ontology Term
Pfam:PF12552 | Protein of unknown function (DUF3741)
Description: This domain family is found in eukaryotes, and is approximately 50 amino acids in length.
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Ontology Term
PANTHER:PTHR10014 | BASIC HELIX-LOOP-HELIX/LEUCINE ZIPPER TRANSCRIPTION FACTOR
 
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Ontology Term
PANTHER:PTHR23073:SF9 | 26S PROTEASE REGULATORY SUBUNIT 4
 
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Ontology Term
PANTHER:PTHR10484 | HISTONE H4
 
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Ontology Term
PANTHER:PTHR23180:SF35 | ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1
 
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Ontology Term
PANTHER:PTHR24320 | RETINOL DEHYDROGENASE
 
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Ontology Term
PANTHER:PTHR19444 | UNC-93 RELATED
 
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Ontology Term
Pfam:PF05978 | Ion channel regulatory protein UNC-93
Description: The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homologue A (UNC93A), protein unc-93 homologue B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans [1]. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades [2]. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons [3].
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Ontology Term
PANTHER:PTHR14005 | EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT
 
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Ontology Term
PANTHER:PTHR14005:SF0 | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A
 
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Ontology Term
PANTHER:PTHR23428 | HISTONE H2B
 
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Ontology Term
PANTHER:PTHR31689 | DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC
 
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