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Search results 2601 to 2700 out of 202262 for *

Category restricted to OntologyTerm (x)

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Category: OntologyTerm
Type Details Score
Ontology Term  
Ontology Term
Description: The XS (rice gene X and SGS3) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2 and SGS3 Swiss:Q9LDX1. SGS3 is thought to be involved in post-transcriptional gene silencing (PTGS). This domain contains a conserved aspartate residue that may be functionally important. The XS domain has recently been predicted to possess an RRM-like RNA-binding domain [1] by fold recognition.
Ontology Term
Description: The XH (rice gene X Homology) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2. The molecular function of these proteins is unknown. However these proteins usually contain an XS domain that is also found in the PTGS protein SGS3. This domain contains a conserved glutamate residue that may be functionally important.
Ontology Term
Description: This domain is a putative nucleic acid binding zinc finger found in proteins that also contain an XS domain.
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Ontology Term
Description: Triosephosphate isomerase (EC:5.3.1.1) (TIM) [1] is the glycolytic enzyme that catalyses the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism [2,3]. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure [4]. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder [5].
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Description: NULL
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Ontology Term
Description: At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus [2]. It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for ribosome nucleus export [1]. This family was formerly known as UPF0120.
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Description: NULL
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Description: This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.
Ontology Term
Description: The members of this family include sequences that are parts of hypothetical proteins expressed by plant species. The region in question is about 170 amino acids long.
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Description: NULL
Ontology Term
Description: The N-terminal domain appears to be specific to the eukaryotic ribosomal proteins L25, L23, and L23a.
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Ontology Term
Description: GTP cyclohydrolase II catalyses the first committed step in the biosynthesis of riboflavin.
Ontology Term
Description: 3,4-Dihydroxy-2-butanone 4-phosphate is biosynthesised from ribulose 5-phosphate and serves as the biosynthetic precursor for the xylene ring of riboflavin. Sometimes found as a bifunctional enzyme with Pfam:PF00925.
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Description: This family includes transporters with a specificity for UDP-N-acetylglucosamine [1].
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Description: NULL
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Description: The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae [1], Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast [1]. Exo70 interacts with the Rho3 GTPase [4]. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud) [3]. In humans, the functions of Exo70 and the exocyst complex are less well characterised: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis [2].
Ontology Term  
Ontology Term
Description: NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.
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Description: Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.
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Ontology Term
Description: This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes [1]. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal [1,2]. It has roles in proton transport and assembly of the V-type ATPase complex [1,2]. This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [2].
Ontology Term
Description: Nodulin is a plant protein of unknown function. It is induced during nodulation in legume roots after rhizobium infection.
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Ontology Term
Description: This domain is structurally related to the PreATP-grasp domain. The family contains the N-terminus of biotin carboxylase enzymes [1,3], and propionyl-CoA carboxylase A chain [2].
Ontology Term
Description: Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. The ATP binding domain (this one) has an ATP-grasp fold.
Ontology Term
Description: Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain.
Ontology Term
Description: This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site [1].
Ontology Term
Description: This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1 [1,2,3]. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU [4], however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU [1,5]. The role of CCDC90B proteins is still not known.
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Description: Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers [1]. Membralin-like gene homologues have been identified in plants including grape, cotton and tomato [2].
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Description: The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see Pfam:PF00514).
Ontology Term
Description: The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see Pfam:PF00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
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Description: This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4 [1]. TRM13 shows no sequence similarity to other known methyltransferases.
Ontology Term
Description: This zinc binding domain [1] has four conserved zinc chelating residues in a CHHC pattern. This domain is predicted to have an RNA-binding function [1].
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Description: This domain is found at the N-terminus of TRM13 methyltransferase proteins. It is presumed to be a zinc binding domain.
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Description: Members of this family are aldolase enzymes that catalyse the first step of the shikimate pathway.
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Description: NULL
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Description: There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
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Description: NULL
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Description: This region is found a the C terminal of proteins belonging to the sorting nexin family. It is found on proteins which also contain Pfam:PF00787.
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Description: This domain is associated with PX domains Pfam:PF00787.
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Description: This is a family of site-specific DNA endonucleases encoded by DNA mobile elements. Similar to Pfam:PF00961, the members of this family are also LAGLIDADG endonucleases.
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Description: NULL
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Description: NULL
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Description: This family represents a family of plant microtubule-associated proteins of size 70 kDa. The proteins contain four predicted coiled-coil domains, and truncation studies identify a central domain that targets the proteins to microtubules. It has no predicted trans-membrane domains, and the region between the coils from approximately residues 240-483 is the targetting region [1].
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Description: NULL
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Description: This enzyme domain has a HotDog fold.
Ontology Term
Description: This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments [1].
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