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Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR12298 | PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED
 
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Ontology Term
Pfam:PF04194 | Programmed cell death protein 2, C-terminal putative domain
Description: NULL
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Ontology Term
PANTHER:PTHR19211 | ATP-BINDING TRANSPORT PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR19211:SF26 | ABC TRANSPORTER F FAMILY MEMBER 2-RELATED
 
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Ontology Term
PANTHER:PTHR11404 | SUPEROXIDE DISMUTASE 2
 
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Ontology Term
Pfam:PF00081 | Iron/manganese superoxide dismutases, alpha-hairpin domain
Description: superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin. A small fragment of YTRE_LEPBI matches well - sequencing error?
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Ontology Term
Pfam:PF02777 | Iron/manganese superoxide dismutases, C-terminal domain
Description: superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.
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Ontology Term
PANTHER:PTHR10631 | N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE
 
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Ontology Term
Pfam:PF02005 | N2,N2-dimethylguanosine tRNA methyltransferase
Description: This enzyme EC:2.1.1.32 used S-AdoMet to methylate tRNA. The TRM1 gene of Saccharomyces cerevisiae is necessary for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNAs [1]. The enzyme is found in both eukaryotes and archaebacteria [2]
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Ontology Term
PANTHER:PTHR11452 | ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE
 
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Ontology Term
Pfam:PF02065 | Melibiase
Description: Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K [1]. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
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Ontology Term
PANTHER:PTHR13489 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF09739 | Mini-chromosome maintenance replisome factor
Description: This entry is of proteins of approximately 600 residues in length containing alternating regions of conservation and low complexity. The Arabidopsis protein is a replisome factor found to bind with the mini-chromosome maintenance, MCM-binding, complex and is crucial for efficient DNA replication. The family now spans the full-length proteins.
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Ontology Term
PANTHER:PTHR11946:SF43 | GU4 NUCLEIC-BINDING PROTEIN 1
 
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Ontology Term
Pfam:PF01588 | Putative tRNA binding domain
Description: This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [2], human tyrosyl-tRNA synthetase [1], and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases [2]. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme [2]. This domain may perform a common function in tRNA aminoacylation [1].
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Ontology Term
PANTHER:PTHR21641 | TRANSLATION INITIATION FACTOR-RELATED
 
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Ontology Term
PANTHER:PTHR11726 | 60S RIBOSOMAL PROTEIN L10
 
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Ontology Term
PANTHER:PTHR15860 | UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR15860:SF0 | LP20373P
 
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Ontology Term
PANTHER:PTHR31789 | OS05G0482600 PROTEIN
 
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Ontology Term
PANTHER:PTHR13226:SF14 | PEPTIDASE C78, UBIQUITIN FOLD MODIFIER-SPECIFIC PEPTIDASE 1/ 2
 
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Ontology Term
PANTHER:PTHR23294 | ET TRANSLATION PRODUCT-RELATED
 
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Ontology Term
PANTHER:PTHR23294:SF0 | UNC93-LIKE PROTEIN MFSD11
 
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Ontology Term
PANTHER:PTHR19919 | WD REPEAT CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF02482 | Sigma 54 modulation protein / S30EA ribosomal protein
Description: This Pfam family contains the sigma-54 modulation protein family and the S30AE family of ribosomal proteins which includes the light- repressed protein (lrtA) (Swiss:P47908) [1].
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Ontology Term
Pfam:PF13952 | Domain of unknown function (DUF4216)
Description: This DUF is sometimes found at the C-terminal end of proteins carrying a Transposase_21 domain, Pfam:PF02992.
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Ontology Term
Pfam:PF13963 | Transposase-associated domain
Description: NULL
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Ontology Term
PANTHER:PTHR22957:SF31 | RABGAP/TBC DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR11252 | POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE
 
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Ontology Term
Pfam:PF01138 | 3' exoribonuclease family, domain 1
Description: This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.
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Ontology Term
Pfam:PF03726 | Polyribonucleotide nucleotidyltransferase, RNA binding domain
Description: This family contains the RNA binding domain of Polyribonucleotide nucleotidyltransferase (PNPase) PNPase is involved in mRNA degradation in a 3'-5' direction.
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Ontology Term
PANTHER:PTHR23074:SF20 | GH08677P
 
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Ontology Term
PANTHER:PTHR15922 | NEUROBLASTOMA-AMPLIFIED SEQUENCE
 
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Ontology Term
PANTHER:PTHR15922:SF2 | NEUROBLASTOMA-AMPLIFIED SEQUENCE
 
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Ontology Term
Pfam:PF08314 | Secretory pathway protein Sec39
Description: Mnaimneh et al [1] identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) [2] showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006) [3].
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Ontology Term
PANTHER:PTHR22798 | MCT-1 PROTEIN
 
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Ontology Term
PANTHER:PTHR22798:SF0 | MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1
 
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Ontology Term
Pfam:PF01472 | PUA domain
Description: The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes [1]. It is predicted that the PUA domain is an RNA binding domain.
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Ontology Term
PANTHER:PTHR14136 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF13599 | Pentapeptide repeats (9 copies)
Description: NULL
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Ontology Term
PANTHER:PTHR32002:SF1 | PROTEIN NLP8-RELATED
 
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Ontology Term
PANTHER:PTHR10933 | IMMUNOGLOBULIN-BINDING PROTEIN 1
 
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Ontology Term
Pfam:PF04177 | TAP42-like family
Description: The TOR signalling pathway activates a cell-growth program in response to nutrients [1]. TIP41 (Pfam:PF04176) interacts with TAP42 and negatively regulates the TOR signaling pathway [2].
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Ontology Term
PANTHER:PTHR11262 | HSL AND CLP PROTEASE
 
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Ontology Term
PANTHER:PTHR11262:SF4 | ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL
 
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Ontology Term
PANTHER:PTHR24015:SF237 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF00930 | Dipeptidyl peptidase IV (DPP IV) N-terminal region
Description: This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.
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Ontology Term
PANTHER:PTHR12356 | NUCLEAR MOVEMENT PROTEIN NUDC
 
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Ontology Term
PANTHER:PTHR12356:SF3 | NUCLEAR MIGRATION PROTEIN NUDC
 
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Ontology Term
Pfam:PF13831 | PHD-finger
Description: PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2]. Several PHD fingers have been identified as binding modules of methylated histone H3 [3].
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Ontology Term
PANTHER:PTHR12786:SF2 | SPLICING FACTOR 3A SUBUNIT 3
 
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Ontology Term
Pfam:PF11931 | SF3a60/Prp9 C-terminal
Description: This domain corresponds to the C-terminal region of SF3a60 subunit (Prp9 in yeast counterpart) from the highly conserved heterotrimeric complex SF3a found in eukaryotes. It is essential for pre-mRNA splicing that functions in spliceosome assembly within the mature U2 snRNP (small ribonucleoprotein particle). This domain has two conserved sequence motifs: PIP and CEICG. It contains a zinc-finger domain of the C2H2-type which might be important for RNA binding and protein-protein interactions with components of the SF3b complex [1].
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Ontology Term
PANTHER:PTHR11938:SF1 | FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE 1, CHLOROPLASTIC/MITOCHONDRIAL
 
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Ontology Term
Pfam:PF14691 | Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
Description: Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyses the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds [1]. This domain carries two Fe4-S4 clusters.
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Ontology Term
PANTHER:PTHR24319 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR31814 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR16056 | REGULATOR OF MICROTUBULE DYNAMICS PROTEIN
 
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Ontology Term
PANTHER:PTHR16056:SF2 | TESTIS-EXPRESSED PROTEIN 10
 
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Ontology Term
PANTHER:PTHR11546 | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN
 
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Ontology Term
PANTHER:PTHR30603:SF0 | RNA POLYMERASE SIGMA FACTOR SIGB-RELATED
 
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Ontology Term
PANTHER:PTHR11584 | SERINE/THREONINE PROTEIN KINASE
 
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Ontology Term
Pfam:PF06017 | Unconventional myosin tail, actin- and lipid-binding
Description: Unconventional myosins, ie those that are not found in muscle, have the common, classical-type head domain, sometimes a neck with the IQ calmodulin-binding motifs, and then non-standard tails. These tails determine the subcellular localisation of the unconventional myosins and also help determine their individual functions. The family carries several different unconventional myosins, eg. Myo1f is expressed mainly in immune cells as well as in the inner ear where it can be associated with deafness, Myo1d has a lipid-binding module in their tail and is implicated in endosome vesicle recycling in epithelial cells. Myo1a, b, c and g from various eukaryotes are also found in this family.
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Ontology Term
PANTHER:PTHR10219 | GLYCOLIPID TRANSFER PROTEIN-RELATED
 
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Ontology Term
Pfam:PF08718 | Glycolipid transfer protein (GLTP)
Description: GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids [1][2].
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Ontology Term
PANTHER:PTHR11679:SF3 | VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45
 
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Ontology Term
Pfam:PF02576 | RimP N-terminal domain
Description: This entry represents the N-terminal domain of the ribosome maturation factor RimP (also known as yhbC). RimP facilitates the maturation of the 30S ribosomal subunit [1]. The N-terminal domain contains two alpha-helices and a three-stranded beta-sheet. It is suggested that the N-terminal domain of SP14.3 (RimP orthologue) could function as a protein module that binds to other proteins, especially those that contain highly positively charged surfaces. [2].
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Ontology Term
PANTHER:PTHR11125 | SUPPRESSOR OF TY 5
 
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Ontology Term
PANTHER:PTHR11125:SF7 | TRANSCRIPTION ELONGATION FACTOR SPT5
 
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Ontology Term
Pfam:PF03439 | Early transcription elongation factor of RNA pol II, NGN section
Description: Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4 [1]. Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit [2].
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Ontology Term
Pfam:PF01803 | LIM-domain binding protein
Description: The LIM-domain binding protein, binds to the LIM domain Pfam:PF00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) Swiss:P70662 is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons [4]. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development [2]. The Drosophila protein Chip Swiss:O18353 is required for segmentation and activity of a remote wing margin enhancer [1]. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development [1]. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions [1].
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Ontology Term
Pfam:PF07645 | Calcium-binding EGF domain
Description: NULL
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Ontology Term
Pfam:PF00036 | EF hand
Description: The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.
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Ontology Term
Pfam:PF10664 | Cyanobacterial and plastid NDH-1 subunit M
Description: The proton-pumping NADH:ubiquinone oxidoreductase catalyses the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides. Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 sub-complexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1]. The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms [2]. The three subunits of NDH-1, NdhM, NdhN and NdhO are essential for effecting cyclic electron flow around photosystem I, by supplying extra-ATP for photosynthesis in both plastids and cyanobacteria [3, 4].
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Ontology Term
Pfam:PF13410 | Glutathione S-transferase, C-terminal domain
Description: This domain is closely related to Pfam:PF00043.
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Ontology Term
PANTHER:PTHR11945:SF97 | FLORAL HOMEOTIC PROTEIN PISTILLATA
 
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Ontology Term
PANTHER:PTHR16426 | UBINUCLEIN/YEMANUCLEIN
 
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Ontology Term
PANTHER:PTHR16426:SF5 | YEMANUCLEIN-ALPHA
 
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Ontology Term
Pfam:PF08729 | HPC2 and ubinuclein domain
Description: HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription [1]. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes [2]. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci [3]. HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails [4]. This domain is also referred to as the HRD or Hpc2-related domain.
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Ontology Term
PANTHER:PTHR20275 | NAD KINASE
 
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Ontology Term
PANTHER:PTHR20275:SF0 | NAD KINASE
 
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Ontology Term
Pfam:PF01513 | ATP-NAD kinase N-terminal domain
Description: Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.
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Ontology Term
PANTHER:PTHR32001 | KERATINOCYTE-ASSOCIATED PROTEIN 2
 
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Ontology Term
Pfam:PF09775 | Keratinocyte-associated protein 2
Description: Members of this family comprise various keratinocyte-associated proteins. Their exact function has not, as yet, been determined.
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Ontology Term
PANTHER:PTHR10177:SF49 | CYCLIN-A1-1-RELATED
 
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Ontology Term
PANTHER:PTHR31051 | PROTEASOME ASSEMBLY CHAPERONE 3
 
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Ontology Term
Pfam:PF10178 | Proteasome assembly chaperone 3
Description: PAC3 is a family of eukaryotic proteasome assembly chaperone 3 proteins conserved from fungi to plants to humans. PAC3 plays a crucial part in the assembly of the 20S core proteasome unit, in conjunction with PAC4.
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Ontology Term
PANTHER:PTHR10242 | 8-OXOGUANINE DNA GLYCOSYLASE
 
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Ontology Term
PANTHER:PTHR10242:SF0 | DNA-3-METHYLADENINE GLYCOSYLASE
 
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Ontology Term
Pfam:PF07934 | 8-oxoguanine DNA glycosylase, N-terminal domain
Description: The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18) [1]. The region featured in this family is the N-terminal domain, which is organised into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket [2].
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Ontology Term
PANTHER:PTHR12874 | F-BOX ONLY PROTEIN 48-RELATED
 
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Ontology Term
Pfam:PF07687 | Peptidase dimerisation domain
Description: This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases [1]. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [2]. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.
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Ontology Term
PANTHER:PTHR11458 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE
 
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Ontology Term
PANTHER:PTHR11458:SF0 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE
 
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Ontology Term
Pfam:PF00490 | Delta-aminolevulinic acid dehydratase
Description: NULL
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Ontology Term
PANTHER:PTHR11699:SF15 | ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM O
 
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Ontology Term
PANTHER:PTHR15828 | CYTOKINE RECEPTOR-LIKE FACTOR 3
 
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Ontology Term
PANTHER:PTHR15828:SF1 | ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5
 
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Ontology Term
Pfam:PF03850 | Transcription factor Tfb4
Description: This family appears to be distantly related to the VWA domain.
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Ontology Term
PANTHER:PTHR12831 | TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED
 
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Ontology Term
Pfam:PF05768 | Glutaredoxin-like domain (DUF836)
Description: These proteins are related to the Pfam:PF00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterised member is G4L (Swiss:P68460) from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication [1]. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L [2].
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USDA
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