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Search results 41901 to 42000 out of 44733 for *

Category restricted to GOTerm (x)

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Categories

Category: GOTerm
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Type Details Score
GO Term
GO:0019805 | quinolinate biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.
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GO Term
GO:0036054 | protein-malonyllysine demalonylase activity
Description: Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.
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GO Term
GO:0036055 | protein-succinyllysine desuccinylase activity
Description: Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
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GO Term
GO:0015496 | putrescine:ornithine antiporter activity
Description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out).
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GO Term
GO:0015822 | ornithine transport
Description: The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
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GO Term
GO:0015847 | putrescine transport
Description: The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
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GO Term
GO:0004586 | ornithine decarboxylase activity
Description: Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine.
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GO Term
GO:0050334 | thiaminase activity
Description: Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+).
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GO Term
GO:0050830 | defense response to Gram-positive bacterium
Description: Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
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GO Term
GO:0007517 | muscle organ development
Description: The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
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GO Term
GO:0030594 | neurotransmitter receptor activity
Description: Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
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GO Term
GO:0045031 | ATP-activated adenosine receptor activity
Description: Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP.
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GO Term
GO:2001032 | regulation of double-strand break repair via nonhomologous end joining
Description: Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
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GO Term
GO:0034551 | mitochondrial respiratory chain complex III assembly
Description: The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.
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GO Term
GO:0034121 | regulation of toll-like receptor signaling pathway
Description: Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
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GO Term
GO:0010506 | regulation of autophagy
Description: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
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GO Term
GO:0000492 | box C/D snoRNP assembly
Description: The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
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GO Term
GO:1900758 | negative regulation of D-amino-acid oxidase activity
Description: Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity.
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GO Term
GO:0042622 | photoreceptor outer segment membrane
Description: The membrane surrounding the outer segment of a vertebrate photoreceptor.
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GO Term
GO:0045444 | fat cell differentiation
Description: The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
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GO Term
GO:0047487 | oligogalacturonide lyase activity
Description: Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate.
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GO Term
GO:0034237 | protein kinase A regulatory subunit binding
Description: Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
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GO Term
GO:0005668 | RNA polymerase transcription factor SL1 complex
Description: A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.
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GO Term
GO:0097524 | sperm plasma membrane
Description: A plasma membrane that is part of a sperm cell.
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GO Term
GO:0001881 | receptor recycling
Description: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
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GO Term
GO:0003334 | keratinocyte development
Description: The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.
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GO Term
GO:0044161 | host cell cytoplasmic vesicle
Description: A vesicle formed of membrane or protein, found in the cytoplasm of a host cell.
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GO Term
GO:0071253 | connexin binding
Description: Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions.
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GO Term
GO:0042998 | positive regulation of Golgi to plasma membrane protein transport
Description: Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
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GO Term
GO:0031640 | killing of cells of other organism
Description: Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
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GO Term
GO:0045765 | regulation of angiogenesis
Description: Any process that modulates the frequency, rate or extent of angiogenesis.
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GO Term
GO:0030667 | secretory granule membrane
Description: The lipid bilayer surrounding a secretory granule.
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GO Term
GO:0034397 | telomere localization
Description: Any process in which a telomere is transported to, and/or maintained in, a specific location.
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GO Term
GO:0034993 | meiotic nuclear membrane microtubule tethering complex
Description: A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
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GO Term
GO:0001772 | immunological synapse
Description: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
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GO Term
GO:0097197 | tetraspanin-enriched microdomain
Description: A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities.
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GO Term
GO:0008544 | epidermis development
Description: The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
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GO Term
GO:0001919 | regulation of receptor recycling
Description: Any process that modulates the frequency, rate, or extent of receptor recycling.
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GO Term
GO:0007040 | lysosome organization
Description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
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GO Term
GO:0016197 | endosomal transport
Description: The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
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GO Term
GO:0032008 | positive regulation of TOR signaling
Description: Any process that activates or increases the frequency, rate or extent of TOR signaling.
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GO Term
GO:0042632 | cholesterol homeostasis
Description: Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
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GO Term
GO:0071230 | cellular response to amino acid stimulus
Description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
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GO Term
GO:0031902 | late endosome membrane
Description: The lipid bilayer surrounding a late endosome.
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GO Term
GO:0031005 | filamin binding
Description: Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
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GO Term
GO:0061181 | regulation of chondrocyte development
Description: Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
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GO Term
GO:0061572 | actin filament bundle organization
Description: A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.
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GO Term
GO:0005911 | cell-cell junction
Description: A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
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GO Term
GO:0007605 | sensory perception of sound
Description: The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
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GO Term
GO:0036128 | CatSper complex
Description: A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.
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GO Term
GO:0097228 | sperm principal piece
Description: The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
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GO Term
GO:0007052 | mitotic spindle organization
Description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
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GO Term
GO:0097546 | ciliary base
Description: Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
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GO Term
GO:0106005 | RNA 5'-cap (guanine-N7)-methylation
Description: The process whereby a guanine in 5-cap is methylated at the N7 position of guanine.
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GO Term
GO:0005845 | mRNA cap binding complex
Description: Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
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GO Term
GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining
Description: Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
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GO Term
GO:0099041 | vesicle tethering to Golgi
Description: The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.
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GO Term
GO:0043014 | alpha-tubulin binding
Description: Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
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GO Term
GO:0005769 | early endosome
Description: A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
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GO Term
GO:0045786 | negative regulation of cell cycle
Description: Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
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GO Term
GO:0031210 | phosphatidylcholine binding
Description: Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
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GO Term
GO:0019222 | regulation of metabolic process
Description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
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GO Term
GO:0008518 | folate:anion antiporter activity
Description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.
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GO Term
GO:0015350 | methotrexate transmembrane transporter activity
Description: Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
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GO Term
GO:0015884 | folic acid transport
Description: The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
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GO Term
GO:0051958 | methotrexate transport
Description: The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
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GO Term
GO:0016287 | glycerone-phosphate O-acyltransferase activity
Description: Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA.
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GO Term
GO:0008611 | ether lipid biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
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GO Term
GO:0030520 | intracellular estrogen receptor signaling pathway
Description: Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
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GO Term
GO:0071392 | cellular response to estradiol stimulus
Description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
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GO Term
GO:0047919 | GDP-mannose 6-dehydrogenase activity
Description: Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH.
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GO Term
GO:0042121 | alginic acid biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
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GO Term
GO:0030643 | cellular phosphate ion homeostasis
Description: Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell.
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GO Term
GO:0045936 | negative regulation of phosphate metabolic process
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
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GO Term
GO:0050811 | GABA receptor binding
Description: Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
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GO Term
GO:0032228 | regulation of synaptic transmission, GABAergic
Description: Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
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GO Term
GO:0050429 | calcium-dependent phospholipase C activity
Description: Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.
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GO Term
GO:0051018 | protein kinase A binding
Description: Interacting selectively and non-covalently with any subunit of protein kinase A.
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GO Term
GO:0010739 | positive regulation of protein kinase A signaling
Description: Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
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GO Term
GO:0090036 | regulation of protein kinase C signaling
Description: Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
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GO Term
GO:0030048 | actin filament-based movement
Description: Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
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GO Term
GO:0009142 | nucleoside triphosphate biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
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GO Term
GO:0047736 | cellobiose epimerase activity
Description: Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose.
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GO Term
GO:0006172 | ADP biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate.
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GO Term
GO:0034501 | protein localization to kinetochore
Description: Any process in which a protein is transported to, or maintained at, the kinetochore.
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GO Term
GO:0070551 | endoribonuclease activity, cleaving siRNA-paired mRNA
Description: Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.
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GO Term
GO:0072091 | regulation of stem cell proliferation
Description: Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
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GO Term
GO:0035197 | siRNA binding
Description: Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
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GO Term
GO:0070883 | pre-miRNA binding
Description: Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
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GO Term
GO:0070921 | regulation of production of siRNA involved in chromatin silencing by small RNA
Description: Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA.
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GO Term
GO:1903798 | regulation of production of miRNAs involved in gene silencing by miRNA
Description: Any process that modulates the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
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GO Term
GO:0070578 | RISC-loading complex
Description: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
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GO Term
GO:0005048 | signal sequence binding
Description: Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
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GO Term
GO:0008727 | GDP-mannose mannosyl hydrolase activity
Description: Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+.
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GO Term
GO:0050076 | maleate isomerase activity
Description: Catalysis of the reaction: maleate = fumarate.
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GO Term
GO:0070417 | cellular response to cold
Description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
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GO Term
GO:0009268 | response to pH
Description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
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GO Term
GO:0000783 | nuclear telomere cap complex
Description: A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
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GO Term
GO:0070187 | shelterin complex
Description: A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.
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GO Term
GO:0006907 | pinocytosis
Description: An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane.
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