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Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR10174:SF2 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
 
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Ontology Term
Pfam:PF12661 | Human growth factor-like EGF
Description: hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.
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Ontology Term
Pfam:PF01348 | Type II intron maturase
Description: Group II introns use intron-encoded reverse transcriptase, maturase and DNA endonuclease activities for site-specific insertion into DNA [2]. Although this type of intron is self splicing in vitro they require a maturase protein for splicing in vivo. It has been shown that a specific region of the aI2 intron is needed for the maturase function [1]. This region was found to be conserved in group II introns and called domain X [3].
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Ontology Term
PANTHER:PTHR12154 | GLYCOSYL TRANSFERASE-RELATED
 
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Ontology Term
Pfam:PF08660 | Oligosaccharide biosynthesis protein Alg14 like
Description: Alg14 is involved dolichol-linked oligosaccharide biosynthesis and anchors the catalytic subunit Alg13 to the ER membrane [1].
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Ontology Term
Pfam:PF15277 | Exocyst complex component SEC3 N-terminal PIP2 binding PH
Description: This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the PIP2 head group are conserved. The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables [1].
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Ontology Term
PANTHER:PTHR23073:SF8 | 26S PROTEASOME REGULATORY SUBUNIT 6B HOMOLOG
 
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Ontology Term
Pfam:PF15249 | Conserved region of unknown function on GLTSCR protein
Description: This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. It is found on glioma tumour suppressor candidate region gene proteins. ** Forced reload
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Ontology Term
PANTHER:PTHR15138 | TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4
 
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Ontology Term
Pfam:PF05236 | Transcription initiation factor TFIID component TAF4 family
Description: This region of similarity is found in Transcription initiation factor TFIID component TAF4 [1].
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Ontology Term
Pfam:PF09741 | Uncharacterized conserved protein (DUF2045)
Description: This entry is the conserved 250 residues of proteins of approximately 450 amino acids. It contains several highly conserved motifs including a CVxLxxxD motif.The function is unknown.
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Ontology Term
PANTHER:PTHR24012:SF0 | FI20028P1
 
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Ontology Term
Pfam:PF02018 | Carbohydrate binding domain
Description: This family includes diverse carbohydrate binding domains.
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Ontology Term
Pfam:PF10258 | Phosphorylated adapter RNA export protein, RNA-binding domain
Description: The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription [1, 2]. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterised by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains [2].
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Ontology Term
PANTHER:PTHR21329:SF8 | TP53-REGULATED INHIBITOR OF APOPTOSIS 1
 
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Ontology Term
Pfam:PF05254 | Uncharacterised protein family (UPF0203)
Description: This family of proteins is functionally uncharacterised.
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Ontology Term
Pfam:PF11838 | ERAP1-like C-terminal domain
Description: This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.
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Ontology Term
PANTHER:PTHR22807 | NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING
 
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Ontology Term
PANTHER:PTHR22807:SF4 | 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE
 
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Ontology Term
Pfam:PF01189 | 16S rRNA methyltransferase RsmB/F
Description: This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme [1,2]. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA [1,2].
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Ontology Term
Pfam:PF01843 | DIL domain
Description: The DIL domain has no known function.
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Ontology Term
PANTHER:PTHR23240 | DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED
 
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Ontology Term
Pfam:PF07522 | DNA repair metallo-beta-lactamase
Description: The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair [1].
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Ontology Term
PANTHER:PTHR12373 | ENHANCER OF RUDIMENTARY ERH
 
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Ontology Term
PANTHER:PTHR12373:SF0 | ENHANCER OF RUDIMENTARY HOMOLOG
 
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Ontology Term
Pfam:PF01133 | Enhancer of rudimentary
Description: Enhancer of rudimentary is a protein of unknown function that is highly conserved in plants and animals. This protein is found to be an enhancer of the rudimentary gene Swiss:P05990.
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Ontology Term
PANTHER:PTHR10099 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE
 
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Ontology Term
Pfam:PF13507 | CobB/CobQ-like glutamine amidotransferase domain
Description: This family captures members that are not found in Pfam:PF00310, Pfam:PF07685 and Pfam:PF13230.
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Ontology Term
Pfam:PF02769 | AIR synthase related protein, C-terminal domain
Description: This family includes Hydrogen expression/formation protein HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site [1].
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Ontology Term
PANTHER:PTHR15341 | SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR
 
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Ontology Term
PANTHER:PTHR15341:SF3 | NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D
 
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Ontology Term
Pfam:PF04494 | WD40 associated region in TFIID subunit, NTD2 domain
Description: This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly [1]. The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 and N-terminal domain is crucial for homodimerisation [2].
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Ontology Term
Pfam:PF00586 | AIR synthase related protein, N-terminal domain
Description: This family includes Hydrogen expression/formation protein HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain [1].
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Ontology Term
PANTHER:PTHR31356:SF4 | L-ASCORBATE PEROXIDASE 6-RELATED
 
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Ontology Term
PANTHER:PTHR31970:SF0 | MOLYBDATE TRANSPORTER 1
 
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Ontology Term
PANTHER:PTHR10738:SF0 | PROTEIN ARGININE N-METHYLTRANSFERASE 5
 
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Ontology Term
PANTHER:PTHR13242:SF0 | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L
 
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Ontology Term
PANTHER:PTHR21540 | RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2
 
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Ontology Term
PANTHER:PTHR21540:SF0 | PHD FAMILY PROTEIN
 
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Ontology Term
PANTHER:PTHR12649 | PEPTIDYL-TRNA HYDROLASE 2
 
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Ontology Term
PANTHER:PTHR11909:SF18 | CASEIN KINASE I ISOFORM DELTA
 
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Ontology Term
PANTHER:PTHR15502 | CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED
 
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Ontology Term
PANTHER:PTHR15502:SF7 | CALCINEURIN-BINDING PROTEIN CABIN-1
 
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Ontology Term
Pfam:PF12295 | Symplekin tight junction protein C terminal
Description: This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a single completely conserved residue P that may be functionally important. Symplekn has been localized, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Careful analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited, partly but specifically, to the plaque structure of the zonula occludens.
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Ontology Term
PANTHER:PTHR12921:SF0 | UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1
 
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Ontology Term
PANTHER:PTHR23176:SF0 | RHO GTPASE ACTIVATING PROTEIN AT 19D, ISOFORM D
 
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Ontology Term
PANTHER:PTHR11962 | QUEUINE TRNA-RIBOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF01702 | Queuine tRNA-ribosyltransferase
Description: This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine. It catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position [1,2]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues [1].
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Ontology Term
PANTHER:PTHR21338 | MITOCHONDRIAL RIBOSOMAL PROTEIN L41
 
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Ontology Term
Pfam:PF00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Description: The DEP domain [1] is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell [2-3]. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting [4-5]. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit [6-7].
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Ontology Term
PANTHER:PTHR13180:SF0 | GEO04055P1
 
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Ontology Term
PANTHER:PTHR10871 | 30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18
 
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Ontology Term
Pfam:PF00416 | Ribosomal protein S13/S18
Description: This family includes ribosomal protein S13 from prokaryotes and S18 from eukaryotes.
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Ontology Term
PANTHER:PTHR12831:SF0 | GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3
 
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Ontology Term
PANTHER:PTHR32161 | DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR32161:SF1 | DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN-RELATED
 
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Ontology Term
Pfam:PF07676 | WD40-like Beta Propeller Repeat
Description: This family appears to be related to the Pfam:PF00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].
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Ontology Term
Pfam:PF14634 | zinc-RING finger domain
Description: NULL
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Ontology Term
PANTHER:PTHR30612 | SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM
 
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Ontology Term
Pfam:PF01043 | SecA preprotein cross-linking domain
Description: The SecA ATPase is involved in the insertion and retraction of preproteins through the plasma membrane. This domain has been found to cross-link to preproteins, thought to indicate a role in preprotein binding. The pre-protein cross-linking domain is comprised of two sub domains that are inserted within the ATPase domain [1].
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Ontology Term
Pfam:PF07516 | SecA Wing and Scaffold domain
Description: SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner. This family is composed of two C-terminal alpha helical subdomains: the wing and scaffold subdomains [1].
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Ontology Term
Pfam:PF07517 | SecA DEAD-like domain
Description: SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner [1,2]. This domain represents the N-terminal ATP-dependent helicase domain, which is related to the Pfam:PF00270 [3].
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Ontology Term
PANTHER:PTHR31723 | PATHOGENESIS-RELATED FAMILY PROTEIN
 
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Ontology Term
PANTHER:PTHR31723:SF0 | PATHOGENESIS-RELATED PROTEIN
 
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Ontology Term
PANTHER:PTHR10217:SF465 | CYCLIC NUCLEOTIDE-GATED ION CHANNEL 1-RELATED
 
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Ontology Term
Pfam:PF04305 | Protein of unknown function (DUF455)
Description: NULL
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Ontology Term
PANTHER:PTHR12189 | MRNA GUANINE-7- METHYLTRANSFERASE
 
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Ontology Term
Pfam:PF03291 | mRNA capping enzyme
Description: This family of enzymes are related to Pfam:PF03919.
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Ontology Term
PANTHER:PTHR15555 | ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED
 
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Ontology Term
Pfam:PF04925 | SHQ1 protein
Description: S. cerevisiae SHQ1 protein is required for SnoRNAs of the box H/ACA Quantitative accumulation (unpublished).
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Ontology Term
PANTHER:PTHR11054 | 6-PHOSPHOGLUCONOLACTONASE
 
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Ontology Term
Pfam:PF01182 | Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
Description: NULL
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Ontology Term
PANTHER:PTHR19919:SF0 | DDB1- AND CUL4-ASSOCIATED FACTOR 7
 
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Ontology Term
PANTHER:PTHR11695:SF30 | GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR31829 | PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED
 
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Ontology Term
Pfam:PF01680 | SOR/SNZ family
Description: Members of this family are enzymes involved in a new pathway of pyridoxine/pyridoxal 5-phosphate biosynthesis [1]. This family was formerly known as UPF0019.
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Ontology Term
Pfam:PF13638 | PIN domain
Description: Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).
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Ontology Term
PANTHER:PTHR12538 | 40S RIBOSOMAL PROTEIN S26
 
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Ontology Term
PANTHER:PTHR12538:SF0 | 40S RIBOSOMAL PROTEIN S26
 
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Ontology Term
Pfam:PF01283 | Ribosomal protein S26e
Description: NULL
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Ontology Term
PANTHER:PTHR13363 | RING FINGER AND SRY DOMAIN-CONTAINING
 
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Ontology Term
PANTHER:PTHR13363:SF1 | E3 UBIQUITIN-PROTEIN LIGASE RNF123
 
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Ontology Term
PANTHER:PTHR21087 | SHIKIMATE KINASE
 
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Ontology Term
PANTHER:PTHR21087:SF0 | SHIKIMATE KINASE 1, CHLOROPLASTIC-RELATED
 
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Ontology Term
Pfam:PF10243 | Microtubule-binding protein MIP-T3 CH-like domain
Description: This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved [1].
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Ontology Term
PANTHER:PTHR19857 | MITOCHONDRIAL DIVISION PROTEIN 1-RELATED
 
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Ontology Term
PANTHER:PTHR13420 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF02594 | Uncharacterised ACR, YggU family COG1872
Description: NULL
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Ontology Term
PANTHER:PTHR31707:SF1 | PECTINESTERASE 1-RELATED
 
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Ontology Term
PANTHER:PTHR10048:SF22 | PHOSPHATIDYLINOSITOL 4-KINASE BETA
 
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Ontology Term
Pfam:PF08569 | Mo25-like
Description: Mo25-like proteins are involved in both polarised growth and cytokinesis. In fission yeast Mo25 is localised alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner [1,2].
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Ontology Term
PANTHER:PTHR12271 | POLY A POLYMERASE CID PAP -RELATED
 
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Ontology Term
PANTHER:PTHR23115:SF13 | RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF06421 | GTP-binding protein LepA C-terminus
Description: This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins [1].
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Ontology Term
PANTHER:PTHR20835 | E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED
 
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Ontology Term
PANTHER:PTHR20835:SF0 | E3 UBIQUITIN-PROTEIN LIGASE PPP1R11
 
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Ontology Term
Pfam:PF07491 | Protein phosphatase inhibitor
Description: These proteins include Ypi1, (Swiss:P43587), a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor [1] and ppp1r11/hcgv (Swiss:O60927), annotated as having protein phosphatase inhibitor activity [2-3].
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Ontology Term
PANTHER:PTHR24089:SF57 | CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN SCAMC-2
 
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Ontology Term
PANTHER:PTHR12469 | PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF03937 | Flavinator of succinate dehydrogenase
Description: This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans [1]. Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria [2]. This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true. The E. coli protein, YgfY also acts as the antitoxin to the membrane-bound toxin family Cpta, Pfam:PF13166, whose E. coli member YgfX, expressed from the same operon as YgfY [3].
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