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Search results 5401 to 5500 out of 202262 for *

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Categories

Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF09446 | VMA21-like domain
Description: This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localised in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase [1].
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Ontology Term
PANTHER:PTHR11373 | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE
 
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Ontology Term
Pfam:PF01966 | HD domain
Description: HD domains are metal dependent phosphohydrolases.
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Ontology Term
PANTHER:PTHR21250 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR10996:SF16 | FORMATE DEHYDROGENASE 1-RELATED
 
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Ontology Term
PANTHER:PTHR11774:SF6 | PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA
 
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Ontology Term
PANTHER:PTHR17602 | RIBOSOME BIOGENESIS REGULATORY PROTEIN
 
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Ontology Term
PANTHER:PTHR17602:SF4 | RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG
 
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Ontology Term
Pfam:PF04939 | Ribosome biogenesis regulatory protein (RRS1)
Description: This family consists of several eukaryotic ribosome biogenesis regulatory (RRS1) proteins. RRS1 is a nuclear protein that is essential for the maturation of 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae [1].
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Ontology Term
Pfam:PF11317 | Protein of unknown function (DUF3119)
Description: This family of proteins has no known function.
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Ontology Term
PANTHER:PTHR18804 | RIBOSOMAL PROTEIN
 
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Ontology Term
Pfam:PF00444 | Ribosomal protein L36
Description: NULL
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Ontology Term
PANTHER:PTHR10332 | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER
 
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Ontology Term
PANTHER:PTHR10332:SF10 | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4
 
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Ontology Term
Pfam:PF01733 | Nucleoside transporter
Description: This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways [2]. Also in this family is mouse and human nucleolar protein HNP36 Swiss:Q14542 a protein of unknown function; although it has been hypothesised to be a plasma membrane nucleoside transporter [2].
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Ontology Term
PANTHER:PTHR32227:SF32 | GLYCOSYL HYDROLASE FAMILY 17 PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR12374 | TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED
 
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Ontology Term
PANTHER:PTHR19211:SF14 | ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1
 
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Ontology Term
PANTHER:PTHR14593 | WD REPEAT-CONTAINING PROTEIN 11
 
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Ontology Term
PANTHER:PTHR12224 | BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE
 
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Ontology Term
Pfam:PF04724 | Glycosyltransferase family 17
Description: This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression [1,2].
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Ontology Term
PANTHER:PTHR22957:SF34 | PROTEIN TBC-15
 
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Ontology Term
Pfam:PF12068 | Rab-binding domain (RBD)
Description: This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold [1]. This domain is found associated with Pfam:PF00566.
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Ontology Term
Pfam:PF09808 | Small nuclear RNA activating complex (SNAPc), subunit 1
Description: Members of this family are part of the SNAPc complex (SNAPC1) required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.
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Ontology Term
PANTHER:PTHR15131 | SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1
 
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Ontology Term
Pfam:PF12231 | Rap1-interacting factor 1 N terminal
Description: This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.
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Ontology Term
PANTHER:PTHR12979 | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10
 
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Ontology Term
PANTHER:PTHR21373 | GLUCOSE REPRESSIBLE PROTEIN MAK10
 
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Ontology Term
PANTHER:PTHR21373:SF0 | N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT
 
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Ontology Term
Pfam:PF04112 | Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
Description: NatC N(alpha)-terminal acetyltransferases contains Mak10p, Mak31p and Mak3p subunits. All three subunits are associated with each other to form the active complex [1].
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Ontology Term
Pfam:PF05116 | Sucrose-6F-phosphate phosphohydrolase
Description: This family consists of Sucrose-6F-phosphate phosphohydrolase proteins found in plants and cyanobacteria. Sucrose-6(F)-phosphate phosphohydrolase catalyses the final step in the pathway of sucrose biosynthesis [1].
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Ontology Term
PANTHER:PTHR12391 | ARP2/3 COMPLEX 21 KD SUBUNIT
 
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Ontology Term
PANTHER:PTHR12391:SF0 | ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 3
 
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Ontology Term
Pfam:PF04062 | ARP2/3 complex ARPC3 (21 kDa) subunit
Description: The seven component ARP2/3 actin-organising complex is involved in actin assembly and function.
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Ontology Term
PANTHER:PTHR21015:SF21 | MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE 1, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF06925 | Monogalactosyldiacylglycerol (MGDG) synthase
Description: This family represents a conserved region of approximately 180 residues within plant and bacterial monogalactosyldiacylglycerol (MGDG) synthase (EC:2.4.1.46). In Arabidopsis, there are two types of MGDG synthase which differ in their N-terminal portion: type A and type B [1].
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Ontology Term
PANTHER:PTHR31998 | K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP
 
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Ontology Term
PANTHER:PTHR31998:SF0 | PYROPHOSPHATE-ENERGIZED MEMBRANE PROTON PUMP 2-RELATED
 
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Ontology Term
Pfam:PF03030 | Inorganic H+ pyrophosphatase
Description: The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists [1].
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Ontology Term
PANTHER:PTHR24322:SF55 | F28J7.36 PROTEIN
 
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Ontology Term
PANTHER:PTHR30508:SF1 | UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED
 
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Ontology Term
Pfam:PF08847 | Chlororespiratory reduction 6
Description: Chlororespiratory reduction 6 (Crr6) is a factor required for the assembly or stabilisation of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis [1].
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Ontology Term
PANTHER:PTHR23115:SF5 | 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT
 
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Ontology Term
PANTHER:PTHR23329 | TUFTELIN-INTERACTING PROTEIN 11-RELATED
 
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Ontology Term
PANTHER:PTHR11630:SF42 | DNA REPLICATION LICENSING FACTOR MCM5
 
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Ontology Term
PANTHER:PTHR12281 | RP42 RELATED
 
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Ontology Term
Pfam:PF03556 | Cullin binding
Description: This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation [1-3]. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices [1,2].
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Ontology Term
PANTHER:PTHR14773 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR14773:SF0 | WD REPEAT-CONTAINING PROTEIN 76
 
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Ontology Term
Pfam:PF14929 | TAF RNA Polymerase I subunit A
Description: TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilises nucleolar transcription factor 1/UBTF on rDNA.
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Ontology Term
PANTHER:PTHR10612 | APOLIPOPROTEIN D
 
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Ontology Term
PANTHER:PTHR10612:SF7 | APOLIPOPROTEIN D
 
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Ontology Term
Pfam:PF08212 | Lipocalin-like domain
Description: Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The structure is an eight-stranded beta barrel.
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Ontology Term
PANTHER:PTHR24015:SF47 | OS01G0374200 PROTEIN
 
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Ontology Term
PANTHER:PTHR11142:SF0 | TRNA PSEUDOURIDINE SYNTHASE-LIKE 1
 
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Ontology Term
PANTHER:PTHR12775 | PROTEIN C20ORF43 HOMOLOG
 
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Ontology Term
PANTHER:PTHR12775:SF0 | REPLICATION TERMINATION FACTOR 2
 
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Ontology Term
Pfam:PF04641 | Rtf2 RING-finger
Description: It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site [1]. This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family [2].
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Ontology Term
PANTHER:PTHR23027 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF02297 | Cytochrome oxidase c subunit VIb
Description: Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.
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Ontology Term
PANTHER:PTHR14499 | POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING
 
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Ontology Term
PANTHER:PTHR14499:SF11 | PROTEIN F32B4.5, ISOFORM A
 
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Ontology Term
Pfam:PF02789 | Cytosol aminopeptidase family, N-terminal domain
Description: NULL
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Ontology Term
Pfam:PF04086 | Signal recognition particle, alpha subunit, N-terminal
Description: SRP is a complex of six distinct polypeptides and a 7S RNA that is essential for transferring nascent polypeptide chains that are destined for export from the cell to the translocation apparatus of the endoplasmic reticulum (ER) membrane [1]. SRP binds hydrophobic signal sequences as they emerge from the ribosome, and arrests translation.
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Ontology Term
PANTHER:PTHR21659 | HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED
 
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Ontology Term
PANTHER:PTHR21659:SF0 | PROTEIN SNA3-RELATED
 
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Ontology Term
Pfam:PF01679 | Proteolipid membrane potential modulator
Description: Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.
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Ontology Term
Pfam:PF05198 | Translation initiation factor IF-3, N-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR10938 | TRANSLATION INITIATION FACTOR IF-3
 
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Ontology Term
PANTHER:PTHR10938:SF0 | TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00707 | Translation initiation factor IF-3, C-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR13222 | RB1-INDUCIBLE COILED-COIL
 
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Ontology Term
PANTHER:PTHR13222:SF1 | RB1-INDUCIBLE COILED-COIL PROTEIN 1
 
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Ontology Term
Pfam:PF10377 | Autophagy-related protein 11
Description: The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex [1,2] and it is also required for dimerisation and kinase activation of Atg1 [3]. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy [4].
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Ontology Term
Pfam:PF01632 | Ribosomal protein L35
Description: NULL
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Ontology Term
PANTHER:PTHR12169 | ATPASE N2B
 
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Ontology Term
Pfam:PF03969 | AFG1-like ATPase
Description: This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family [1]. LACE1, the mammalian homologue of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain [2]. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro [3].
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Ontology Term
PANTHER:PTHR11845 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF13023 | HD domain
Description: HD domains are metal dependent phosphohydrolases.
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Ontology Term
PANTHER:PTHR11387 | CYTOCHROME C OXIDASE SUBUNIT 6B
 
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Ontology Term
PANTHER:PTHR11387:SF2 | CYTOCHROME C OXIDASE SUBUNIT
 
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Ontology Term
Pfam:PF13088 | BNR repeat-like domain
Description: This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
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Ontology Term
PANTHER:PTHR12818 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR12818:SF0 | TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE
 
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Ontology Term
Pfam:PF01980 | tRNA-methyltransferase O
Description: This family includes members such as TrmO (tRNA-methyltransferase O) also known as YaeB, which contains a single-sheeted beta-barrel structure. TrmO is an AdoMet-dependent methyltransferase responsible for m6t6A formation [1]. Its human homolog, is responsible for formation of m6t6A37 in cytoplasmic tRNASer. Lack of TrmO decreases attenuation activity of the thr operon, indicating that N6 methylation of m6t6A37 ensures efficient decoding of ACY codons [2]. In bacteria and eukaryotes, TrmO has a C-terminal domain containing the conserved DPRxxY motif. Where the Asp194 and Arg196 in this motif of E. coli TrmO are necessary for N6-methylation. However, no archaeal YaeB has a C-terminal domain containing the DPRxxY motif that is conserved in bacterial and mammalian TrmO homologs [1].
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Ontology Term
PANTHER:PTHR18966:SF6 | GLUTAMATE RECEPTOR 1.1-RELATED
 
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Ontology Term
PANTHER:PTHR11193:SF0 | SMALL NUCLEAR RIBONUCLEOPROTEIN E
 
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Ontology Term
Pfam:PF01261 | Xylose isomerase-like TIM barrel
Description: This TIM alpha/beta barrel structure is found in xylose isomerase (Swiss:P19148) and in endonuclease IV (Swiss:P12638, EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae [1].
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Ontology Term
Pfam:PF13500 | AAA domain
Description: This domain is found in a number of proteins involved in cofactor biosynthesis such as dethiobiotin synthase and cobyric acid synthase. This domain contains a P-loop motif.
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Ontology Term
PANTHER:PTHR11214:SF3 | BETA-1,3-GALACTOSYLTRANSFERASE 6
 
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Ontology Term
PANTHER:PTHR21236:SF1 | PROTEIN YIPF6
 
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Ontology Term
Pfam:PF11559 | Afadin- and alpha -actinin-Binding
Description: This family is found in mammals where it is localised at cell-cell adherens junctions [1], and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules [2]. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.
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Ontology Term
PANTHER:PTHR13989 | REPLICATION PROTEIN A-RELATED
 
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Ontology Term
Pfam:PF08784 | Replication protein A C terminal
Description: This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.
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Ontology Term
PANTHER:PTHR21736:SF13 | PROTEIN VERNALIZATION INSENSITIVE 3-RELATED
 
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Ontology Term
PANTHER:PTHR31262:SF0 | RIBULOSE BISPHOSPHATE CARBOXYLASE SMALL SUBUNIT, CHLOROPLASTIC 1
 
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Ontology Term
Pfam:PF08648 | U4/U6.U5 small nuclear ribonucleoproteins
Description: This is a family of eukaryotic proteins including U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein may play a role in mRNA splicing [1].
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Ontology Term
PANTHER:PTHR12734 | METHYLTRANSFERASE-RELATED
 
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Ontology Term
PANTHER:PTHR12734:SF0 | 18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED
 
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Ontology Term
Pfam:PF12589 | Methyltransferase involved in Williams-Beuren syndrome
Description: This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with Pfam:PF08241. This family is made up of S-adenosylmethionine-dependent methyltransferases [1]. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype [2].
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