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Search results 801 to 900 out of 202262 for *

Category restricted to OntologyTerm (x)

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Categories

Category: OntologyTerm
Type Details Score
Ontology Term  
Ontology Term  
Ontology Term
Description: This domain is frequently found at the N-terminus of proteins containing Pfam:PF08458 at the C-terminus. It is a component of the auto-regulatory loop which enables auxin canalisation by recruitment of the PIN1 auxin efflux protein to the cell membrane [1].
Ontology Term
Description: This family describes a pleckstrin homology (PH)-like region found in several plant proteins of unknown function.
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Ontology Term
Description: This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Ontology Term
Description: The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2].
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Description: NULL
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Description: NULL
Ontology Term
Description: The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.
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Description: This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Ontology Term  
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Ontology Term
Description: This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesised polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them [2][3].
Ontology Term  
Ontology Term
Description: This domain is conserved in the A subunits of the proteasome complex proteins.
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Ontology Term
Description: Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange [3]. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [1]. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins [4].
Ontology Term  
Ontology Term
Description: Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.
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Ontology Term
Description: This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter [1]. This family also contains the leukaemia virus receptor Swiss:Q08344.
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Description: NULL
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Ontology Term
Description: Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay [1].
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Description: NULL
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Ontology Term
Description: The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.
Ontology Term
Description: NULL
Ontology Term
Description: This family consists of several hypothetical bacterial and plant proteins of around 125 residues in length. The function of this family is unknown.
Ontology Term  
Ontology Term
Description: Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse[1]. A role of fumble in membrane synthesis has been proposed[1].
Ontology Term  
Ontology Term
Description: This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned region contains two cysteine residues. This domain shows structural similarity to members of the Bet v1-like superfamily [1] and may be involved in lipid binding.
Ontology Term  
Ontology Term
Description: This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.
Ontology Term  
Ontology Term
Description: Glycosyl hydrolase family 28 includes polygalacturonase EC:3.2.1.15 as well as rhamnogalacturonase A(RGase A), EC:3.2.1.-. These enzymes is important in cell wall metabolism.
Ontology Term
Description: This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. In the case of the Arabidopsis protein UniProtKB:Q66GI4, the repeated helices in this N-terminal region, of protein-only RNase P (PRORP) enzymes, form the pentatricopeptide repeat (PPR) domain which enhances pre-tRNA binding affinity. PROPRP enzymes process precursor tRNAs in human mitochondria and in all tRNA-using compartments of Arabidopsis thaliana [1].
Ontology Term
Description: This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.
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Description: NULL
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Description: YABBY proteins are a group of plant-specific transcription involved in the specification of abaxial polarity in lateral organs [1,2].
Ontology Term
Description: This domain is very short and is found at the N-terminal of many Gag-pol polyprotein and related proteins. There is a highly conserved YxxWxxxM sequence motif.
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Description: NULL
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Description: This enzyme catalyses the conversion of D-ribulose 5-phosphate into D-xylulose 5-phosphate.
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Ontology Term
Description: The PC-Esterase family [1] is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1 [2][3], animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily [1]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [1][3]. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity [1]. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes [1]. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain [1].
Ontology Term
Description: The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain [1].
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Description: Other tRNA synthetase sub-families are too dissimilar to be included.
Ontology Term
Description: This domain is often found in association with the kinase domains Pfam:PF00069 or Pfam:PF07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges [1]. It has a role in salt stress response [2] and has antifungal activity [3].
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Description: NULL
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Description: This family represents a group of putative heme-binding proteins [1]. Our family includes archaeal and bacterial homologues.
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Description: This family also contains members which are coatomer subunits.
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Description: NULL
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Description: This domain is related to the Glyoxalase domain Pfam:PF00903.
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Description: NULL
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Description: Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localised to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localise predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress [2]. BI-1 appears to exert its effect through an interaction with calmodulin [3]. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner [4]. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition [5].
Ontology Term  
Ontology Term
Description: Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.
Ontology Term
Description: Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.
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Description: NULL
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Description: This family includes carbonic anhydrases as well as a family of non-functional homologues related to YbcF.
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