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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF02728 | Copper amine oxidase, N3 domain
Description: This domain is the second or third structural domain in copper amine oxidases, it is known as the N3 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).
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Ontology Term
PANTHER:PTHR11109 | GTP CYCLOHYDROLASE I
 
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Ontology Term
Pfam:PF01227 | GTP cyclohydrolase I
Description: This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.
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Ontology Term
PANTHER:PTHR13301 | X-BOX TRANSCRIPTION FACTOR-RELATED
 
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Ontology Term
Pfam:PF03162 | Tyrosine phosphatase family
Description: This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.
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Ontology Term
Pfam:PF14569 | Zinc-binding RING-finger
Description: This RING/U-box type zinc-binding domain is frequently found in the catalytic subunit (irx3) of cellulose synthase. The enzymic class is EC:2.4.1.12, whereby the synthase removes the glucose from UDP-glucose and adds it to the growing cellulose, thereby releasing UDP. The domain-structure is treble-clef like (PDB:1weo).
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Ontology Term
PANTHER:PTHR11699 | ALDEHYDE DEHYDROGENASE-RELATED
 
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Ontology Term
PANTHER:PTHR11699:SF46 | ALDEHYDE DEHYDROGENASE
 
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Ontology Term
Pfam:PF00171 | Aldehyde dehydrogenase family
Description: This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases Swiss:P00352 EC:1.2.1.3. Succinate-semialdehyde dehydrogenase Swiss:P25526 EC:1.2.1.16. Lactaldehyde dehydrogenase Swiss:P25553 EC:1.2.1.22. Benzaldehyde dehydrogenase Swiss:P43503 EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase Swiss:Q02252 EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase Swiss:P81406 EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase Swiss:P30038 EC: 1.5.1.12. Acetaldehyde dehydrogenase Swiss:P17547 EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase Swiss:P07004 EC:1.2.1.41. This family also includes omega crystallin Swiss:P30842 an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.
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Ontology Term
PANTHER:PTHR24223 | ATP-BINDING CASSETTE SUB-FAMILY C
 
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Ontology Term
Pfam:PF00005 | ABC transporter
Description: ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.
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Ontology Term
Pfam:PF00664 | ABC transporter transmembrane region
Description: This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (Pfam:PF00005) have two such regions.
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Ontology Term
PANTHER:PTHR11409 | ADENOSINE DEAMINASE
 
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Ontology Term
PANTHER:PTHR11409:SF21 | ADENOSINE DEAMINASE-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR32227 | GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED
 
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Ontology Term
Pfam:PF00332 | Glycosyl hydrolases family 17
Description: NULL
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Ontology Term
Pfam:PF07983 | X8 domain
Description: The X8 domain [2] domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen [1] as well as at the C-terminus of several families of glycosyl hydrolases [2]. This domain may be involved in carbohydrate binding. This domain is characteristic of GPI-anchored domains [4,5].
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Ontology Term
Pfam:PF00254 | FKBP-type peptidyl-prolyl cis-trans isomerase
Description: NULL
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Ontology Term
PANTHER:PTHR32448 | OS08G0158400 PROTEIN
 
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Ontology Term
PANTHER:PTHR32448:SF11 | BERBERINE BRIDGE ENZYME-RELATED
 
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Ontology Term
PANTHER:PTHR10394 | 40S RIBOSOMAL PROTEIN S8
 
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Ontology Term
Pfam:PF01201 | Ribosomal protein S8e
Description: NULL
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Ontology Term
PANTHER:PTHR12565 | STEROL REGULATORY ELEMENT-BINDING PROTEIN
 
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Ontology Term
Pfam:PF01419 | Jacalin-like lectin domain
Description: Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein (Swiss:P15501).
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Ontology Term
PANTHER:PTHR22881 | BROMODOMAIN CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR13020 | TRINUCLEOTIDE REPEAT-CONTAINING GENE 6
 
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Ontology Term
PANTHER:PTHR11926:SF77 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF03033 | Glycosyltransferase family 28 N-terminal domain
Description: The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.
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Ontology Term
Pfam:PF12483 | E3 Ubiquitin ligase
Description: This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.
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Ontology Term
PANTHER:PTHR11680 | SERINE HYDROXYMETHYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR11680:SF0 | SERINE HYDROXYMETHYLTRANSFERASE
 
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Ontology Term
Pfam:PF00464 | Serine hydroxymethyltransferase
Description: NULL
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Ontology Term
PANTHER:PTHR32018 | RHAMNOGALACTURONATE LYASE FAMILY PROTEIN
 
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Ontology Term
Pfam:PF06045 | Rhamnogalacturonate lyase family
Description: Rhamnogalacturonate lyase (EC:4.2.2.-) degrades the rhamnogalacturonan I (RG-I) backbone of pectin [1]. This family contains mainly members from plants, but also contains the plant pathogen Erwinia chrysanthemi.
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Ontology Term
Pfam:PF14683 | Polysaccharide lyase family 4, domain III
Description: CBM-like is domain III of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain possesses a jelly roll beta-sandwich fold structurally homologous to carbohydrate binding modules (CBMs), and it carries two sulfate ions and a hexa-coordinated calcium ion.
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Ontology Term
Pfam:PF14686 | Polysaccharide lyase family 4, domain II
Description: FnIII-like is domain II of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain displays an immunoglobulin-like or more specifically Fibronectin-III type fold and shows highest structural similarity to the C-terminal beta-sandwich subdomain of the pro-hormone/propeptide processing enzyme carboxypeptidase gp180 from duck. It serves to assist in producing the deep pocket, with domain III, into which the substrate fits [1].
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Ontology Term
PANTHER:PTHR12029 | RNA METHYLTRANSFERASE
 
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Ontology Term
Pfam:PF00588 | SpoU rRNA Methylase family
Description: This family of proteins probably use S-AdoMet.
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Ontology Term
PANTHER:PTHR11502 | 40S RIBOSOMAL PROTEIN S6
 
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Ontology Term
Pfam:PF01092 | Ribosomal protein S6e
Description: NULL
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Ontology Term
PANTHER:PTHR31391 | B3 DOMAIN-CONTAINING PROTEIN OS11G0197600-RELATED
 
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Ontology Term
Pfam:PF06521 | PAR1 protein
Description: This family consists of several plant specific PAR1 proteins from Nicotiana tabacum and Arabidopsis thaliana. The function of this family is unknown.
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Ontology Term
PANTHER:PTHR30265 | RHO-INTERACTING TRANSCRIPTION TERMINATION FACTOR NUSG
 
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Ontology Term
Pfam:PF00467 | KOW motif
Description: This family has been extended to coincide with ref [1]. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.
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Ontology Term
Pfam:PF02357 | Transcription termination factor nusG
Description: NULL
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Ontology Term
PANTHER:PTHR15858 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR15858:SF0 | IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1
 
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Ontology Term
Pfam:PF08571 | Yos1-like
Description: In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Yos1 appears to be conserved in eukaryotes[1].
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Ontology Term
PANTHER:PTHR31741 | OS02G0726500 PROTEIN-RELATED
 
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Ontology Term
Pfam:PF10250 | GDP-fucose protein O-fucosyltransferase
Description: This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese [1].
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Ontology Term
PANTHER:PTHR13622 | THIAMIN PYROPHOSPHOKINASE
 
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Ontology Term
PANTHER:PTHR11814 | SULFATE TRANSPORTER
 
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Ontology Term
Pfam:PF00916 | Sulfate permease family
Description: This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.
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Ontology Term
Pfam:PF12481 | Aluminium induced protein
Description: This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: YGL and LRDR. This family is related to GATase enzyme domains.
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Ontology Term
PANTHER:PTHR11132 | SOLUTE CARRIER FAMILY 35
 
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Ontology Term
Pfam:PF03151 | Triose-phosphate Transporter family
Description: This family includes transporters with a specificity for triose phosphate [1].
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Ontology Term
PANTHER:PTHR14159 | ATAXIN-3-RELATED
 
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Ontology Term
PANTHER:PTHR14159:SF0 | ATAXIN-3-RELATED
 
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Ontology Term
Pfam:PF02099 | Josephin
Description: NULL
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Ontology Term
PANTHER:PTHR21419 | FAMILY NOT NAMED
 
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Ontology Term
Pfam:PF01839 | FG-GAP repeat
Description: This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure [1]. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat [1]. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding [2]. A putative Ca2+ binding motif is found in some of the repeats.
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Ontology Term
PANTHER:PTHR11017 | LEUCINE-RICH REPEAT-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF00931 | NB-ARC domain
Description: NULL
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Ontology Term
Pfam:PF01582 | TIR domain
Description: The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (Swiss:Q99836) and TOLLIP (Toll interacting protein, Swiss:Q9H0E2). In turn, these associate with various kinases to set off signalling cascades [3].
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Ontology Term
Pfam:PF01301 | Glycosyl hydrolases family 35
Description: NULL
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Ontology Term
PANTHER:PTHR10639 | CLATHRIN LIGHT CHAIN
 
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Ontology Term
Pfam:PF01086 | Clathrin light chain
Description: NULL
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Ontology Term
Pfam:PF06075 | Plant protein of unknown function (DUF936)
Description: This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.
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Ontology Term
PANTHER:PTHR22573 | PHOSPHOHEXOMUTASE FAMILY MEMBER
 
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Ontology Term
Pfam:PF02879 | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
Description: NULL
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Ontology Term
Pfam:PF03849 | Transcription factor Tfb2
Description: NULL
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Ontology Term
PANTHER:PTHR13711 | SWI/SNF-RELATED CHROMATIN BINDING PROTEIN
 
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Ontology Term
Pfam:PF00505 | HMG (high mobility group) box
Description: NULL
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Ontology Term
PANTHER:PTHR13878 | GULONOLACTONE OXIDASE
 
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Ontology Term
Pfam:PF00742 | Homoserine dehydrogenase
Description: NULL
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Ontology Term
Pfam:PF03016 | Exostosin family
Description: The EXT family is a family of tumour suppressor genes. Mutations of EXT1 Swiss:Q16394 on 8q24.1, EXT2 Swiss:Q93063 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities [1]. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.
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Ontology Term
Pfam:PF04030 | D-arabinono-1,4-lactone oxidase
Description: This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.- , which is involved in the final step of the D-erythroascorbic acid biosynthesis pathway [1].
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Ontology Term
PANTHER:PTHR19918 | CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED
 
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Ontology Term
PANTHER:PTHR12486 | APRATAXIN-RELATED
 
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Ontology Term
PANTHER:PTHR12486:SF4 | APRATAXIN
 
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Ontology Term
Pfam:PF11969 | Scavenger mRNA decapping enzyme C-term binding
Description: This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.
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Ontology Term
Pfam:PF13671 | AAA domain
Description: This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.
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Ontology Term
PANTHER:PTHR13691 | RIBOSOMAL PROTEIN L2
 
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Ontology Term
Pfam:PF03947 | Ribosomal Proteins L2, C-terminal domain
Description: NULL
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Ontology Term
Pfam:PF08284 | Retroviral aspartyl protease
Description: Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases.
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Ontology Term
Pfam:PF04258 | Signal peptide peptidase
Description: The members of this family are membrane proteins. In some proteins this region is found associated with Pfam:PF02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with Pfam:PF01080.
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Ontology Term
PANTHER:PTHR18968 | THIAMINE PYROPHOSPHATE ENZYMES
 
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Ontology Term
PANTHER:PTHR18968:SF4 | PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED
 
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Ontology Term
Pfam:PF02776 | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Description: NULL
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Ontology Term
PANTHER:PTHR22600 | BETA-HEXOSAMINIDASE
 
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Ontology Term
Pfam:PF00728 | Glycosyl hydrolase family 20, catalytic domain
Description: This domain has a TIM barrel fold.
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Ontology Term
Pfam:PF06694 | Plant nuclear matrix protein 1 (NMP1)
Description: This family consists of several plant specific nuclear matrix protein 1 (NMP1) sequences. Nuclear Matrix Protein 1 is a ubiquitously expressed 36 kDa protein, which has no homologues in animals and fungi, but is highly conserved among flowering and non-flowering plants. NMP1 is located both in the cytoplasm and nucleus and that the nuclear fraction is associated with the nuclear matrix. NMP1 is a candidate for a plant-specific structural protein with a function both in the nucleus and cytoplasm [1].
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Ontology Term
Pfam:PF11721 | Malectin domain
Description: Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan [1].
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Ontology Term
PANTHER:PTHR10804 | PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P
 
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Ontology Term
PANTHER:PTHR10804:SF11 | PROLIFERATION-ASSOCIATED PROTEIN 2G4
 
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Ontology Term
Pfam:PF00557 | Metallopeptidase family M24
Description: This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3].
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Ontology Term
PANTHER:PTHR11359 | AMP DEAMINASE
 
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Ontology Term
Pfam:PF00962 | Adenosine deaminase
Description: NULL
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Ontology Term
Pfam:PF00477 | Small hydrophilic plant seed protein
Description: NULL
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Ontology Term
PANTHER:PTHR13544 | SELENOPROTEIN T
 
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