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Search results 2501 to 2600 out of 202262 for *

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Categories

Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF02150 | RNA polymerases M/15 Kd subunit
Description: NULL
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Ontology Term
PANTHER:PTHR16266 | WD REPEAT DOMAIN 9
 
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Ontology Term
Pfam:PF00439 | Bromodomain
Description: Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].
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Ontology Term
PANTHER:PTHR32227:SF33 | BETA-1,3-GLUCANASE 1-RELATED
 
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Ontology Term
PANTHER:PTHR11699:SF25 | ALDEHYDE DEHYDROGENASE-LIKE PROTEIN YHR039C-RELATED
 
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Ontology Term
PANTHER:PTHR13484 | FIP1-LIKE 1 PROTEIN
 
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Ontology Term
Pfam:PF05182 | Fip1 motif
Description: This short motif is about 40 amino acids in length. In the Fip1 protein that is a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase [1]. This region of Fip1 is needed for the interaction with the Th1 subunit of the complex and for specific polyadenylation of the cleaved mRNA precursor [2].
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Ontology Term
PANTHER:PTHR23118 | ATP-CITRATE SYNTHASE
 
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Ontology Term
Pfam:PF00285 | Citrate synthase, C-terminal domain
Description: This is the long, C-terminal part of the enzyme.
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Ontology Term
Pfam:PF00549 | CoA-ligase
Description: This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP.
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Ontology Term
Pfam:PF00360 | Phytochrome region
Description: Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to Pfam:PF01590 [1], which is generally located immediately N-terminal to this domain. Compared with Pfam:PF01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilise the photoactivated far-red-absorbing state (Pfr) [1]. The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue [1].
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Ontology Term
Pfam:PF00989 | PAS fold
Description: The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
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Ontology Term
Pfam:PF08446 | PAS fold
Description: The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.
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Ontology Term
PANTHER:PTHR31184 | HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR12409 | PREFOLDIN SUBUNIT 3
 
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Ontology Term
Pfam:PF02996 | Prefoldin subunit
Description: This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT [1].
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Ontology Term
PANTHER:PTHR20994 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF07019 | EMC6
Description: This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER membrane protein complex subunit 6 (EMC6) and RCAF1. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5 [1]. EMC6 interacts with Rab5A and BECN1/Beclin 1 and regulates autophagosome formation [2]. EMC6 is part of the EMC complex, required for efficient folding of proteins in the ER [3] and for post-translational membrane insertion of tail-anchored (TA) proteins [4,5].
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Ontology Term
PANTHER:PTHR31694 | DESICCATION-LIKE PROTEIN
 
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Ontology Term
Pfam:PF13668 | Ferritin-like domain
Description: This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.
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Ontology Term
Pfam:PF14901 | Cleavage inducing molecular chaperone
Description: Jiv90 is a fragment of the DnaJ protein in eukaryotes and in J-domain protein interacting with viral protein (Jiv) located in the N terminal region of the pestivirus viral polypeptide. The viral protein interacts stably with non structural (NS) protein NS2, causing a conformational change in NS2-NS3 and stimulates NS2-NS3 cleavage in trans. Cleavage of NS2-NS3 increases cytopathogenicity and consequently aids viral replication. Jiv therefore acts as a regulating cofactor for NS2 auto-protease. The efficient release of NS3 from the viral polypeptide by Jiv is considered crucial to the pestivirus cytopathogenicity [1]. In eukaryotes, it usually lies 40 residues downstream of DnaJ family Pfam:PF00226. However, the function in eukaryotes is still unknown.
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Ontology Term
PANTHER:PTHR31264 | OS07G0554500 PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR11875 | TESTIS-SPECIFIC Y-ENCODED PROTEIN
 
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Ontology Term
PANTHER:PTHR11875:SF7 | AT14585P-RELATED
 
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Ontology Term
Pfam:PF00956 | Nucleosome assembly protein (NAP)
Description: NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.
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Ontology Term
PANTHER:PTHR24092 | PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE
 
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Ontology Term
PANTHER:PTHR10113 | PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
 
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Ontology Term
Pfam:PF03464 | eRF1 domain 2
Description: The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown. Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.
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Ontology Term
Pfam:PF03465 | eRF1 domain 3
Description: The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown. Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.
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Ontology Term
PANTHER:PTHR24089:SF41 | SOLUTE CARRIER FAMILY 25 MEMBER 44
 
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Ontology Term
PANTHER:PTHR12854 | ATAXIN 2-RELATED
 
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Ontology Term
Pfam:PF06741 | LsmAD domain
Description: This domain is found associated with Lsm domain [1].
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Ontology Term
Pfam:PF14438 | Ataxin 2 SM domain
Description: This SM domain is found in Ataxin-2 [1].
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Ontology Term
PANTHER:PTHR22957:SF26 | LD44506P
 
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Ontology Term
PANTHER:PTHR19332 | PEROXISOMAL MEMBRANE PROTEIN PEX13
 
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Ontology Term
PANTHER:PTHR19332:SF1 | PEROXISOMAL MEMBRANE PROTEIN PEX13
 
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Ontology Term
PANTHER:PTHR14000 | FINGER CCCH DOMAIN PROTEIN, PUTATIVE (DUF3755)-RELATED
 
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Ontology Term
Pfam:PF12579 | Protein of unknown function (DUF3755)
Description: This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a single completely conserved residue N that may be functionally important.
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Ontology Term
Pfam:PF04266 | ASCH domain
Description: The ASCH domain adopts a beta-barrel fold similar to the Pfam:PF01472 domain [1]. It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation [1].
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Ontology Term
PANTHER:PTHR10965 | 60S RIBOSOMAL PROTEIN L38
 
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Ontology Term
Pfam:PF01781 | Ribosomal L38e protein family
Description: NULL
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Ontology Term
PANTHER:PTHR31928 | EXPRESSED PROTEIN
 
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Ontology Term
PANTHER:PTHR11935 | BETA LACTAMASE DOMAIN
 
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Ontology Term
PANTHER:PTHR11935:SF7 | HYDROXYACYLGLUTATHIONE HYDROLASE 2, CHLOROPLASTIC-RELATED
 
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Ontology Term
Pfam:PF00753 | Metallo-beta-lactamase superfamily
Description: NULL
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Ontology Term
PANTHER:PTHR23189 | RNA RECOGNITION MOTIF-CONTAINING
 
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Ontology Term
Pfam:PF07744 | SPOC domain
Description: The SPOC (Spen paralogue and orthologue C-terminal) domain is involved in developmental signalling [1].
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Ontology Term
PANTHER:PTHR13690 | TRANSCRIPTION FACTOR POSF21-RELATED
 
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Ontology Term
Pfam:PF05187 | Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
Description: Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4Fe4S] cluster, are present in a 64-kDa monomer [1].
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Ontology Term
Pfam:PF13450 | NAD(P)-binding Rossmann-like domain
Description: NULL
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Ontology Term
PANTHER:PTHR10426 | STRICTOSIDINE SYNTHASE-RELATED
 
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Ontology Term
Pfam:PF14953 | Domain of unknown function (DUF4504)
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.
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Ontology Term
PANTHER:PTHR10584 | SUGAR KINASE
 
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Ontology Term
Pfam:PF00294 | pfkB family carbohydrate kinase
Description: This family includes a variety of carbohydrate and pyrimidine kinases.
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Ontology Term
PANTHER:PTHR12444 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF01239 | Protein prenyltransferase alpha subunit repeat
Description: Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognise a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognises a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family [2].
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Ontology Term
PANTHER:PTHR11129 | PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT
 
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Ontology Term
PANTHER:PTHR11129:SF1 | PROTEIN FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA
 
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Ontology Term
PANTHER:PTHR21095 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR11685:SF10 | E3 UBIQUITIN-PROTEIN LIGASE ARIH1
 
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Ontology Term
PANTHER:PTHR22754 | DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED
 
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Ontology Term
PANTHER:PTHR22754:SF4 | DISCO-INTERACTING PROTEIN 2
 
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Ontology Term
Pfam:PF00199 | Catalase
Description: NULL
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Ontology Term
PANTHER:PTHR31029 | CYCLIN-DEPENDENT KINASE-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR11426 | HISTONE H3
 
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Ontology Term
PANTHER:PTHR31151 | PROLINE-TRNA LIGASE (DUF1680)
 
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Ontology Term
PANTHER:PTHR31151:SF0 | PROLINE-TRNA LIGASE (DUF1680)
 
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Ontology Term
Pfam:PF07944 | Beta-L-arabinofuranosidase, GH127
Description: One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterised as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context [1].
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Ontology Term
PANTHER:PTHR11158 | MSF1/PX19 RELATED
 
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Ontology Term
Pfam:PF04707 | PRELI-like family
Description: This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.
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Ontology Term
PANTHER:PTHR11065 | SOLUTE CARRIER FAMILY 39 (METAL ION TRANSPORTER), MEMBER 11
 
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Ontology Term
Pfam:PF02535 | ZIP Zinc transporter
Description: The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant [1]. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.
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Ontology Term
PANTHER:PTHR12815 | SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER
 
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Ontology Term
Pfam:PF01103 | Omp85 superfamily domain
Description: The Omp85 protein superfamily contains bacterial outer membrane proteins, which can function as protein translocases or as membrane protein assembly factors [1]. The family includes the membrane bound beta barrel of proteins such as BamA and TamA from E. coli.
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Ontology Term
Pfam:PF07244 | Surface antigen variable number repeat
Description: This family is found primarily in bacterial surface antigens, normally as variable number repeats at the N-terminus. The C-terminus of these proteins is normally represented by Pfam:PF01103. The alignment centres on a -GY- or -GF- motif. Some members of this family are found in the mitochondria. It is predicted to have a mixed alpha/beta secondary structure.
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Ontology Term
PANTHER:PTHR24089:SF31 | ADP,ATP CARRIER PROTEIN-RELATED
 
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Ontology Term
Pfam:PF04554 | Extensin-like region
Description: NULL
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Ontology Term
Pfam:PF00941 | FAD binding domain in molybdopterin dehydrogenase
Description: NULL
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Ontology Term
Pfam:PF01315 | Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Description: NULL
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Ontology Term
Pfam:PF01799 | [2Fe-2S] binding domain
Description: NULL
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Ontology Term
Pfam:PF03450 | CO dehydrogenase flavoprotein C-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR10983 | 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED
 
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Ontology Term
PANTHER:PTHR24012:SF55 | TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1
 
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Ontology Term
PANTHER:PTHR10763 | CELL DIVISION CONTROL PROTEIN 6-RELATED
 
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Ontology Term
PANTHER:PTHR10763:SF6 | ORIGIN RECOGNITION COMPLEX SUBUNIT 1
 
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Ontology Term
Pfam:PF13692 | Glycosyl transferases group 1
Description: NULL
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Ontology Term
PANTHER:PTHR20648 | ELONGIN-C
 
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Ontology Term
PANTHER:PTHR20648:SF0 | ELONGIN-C
 
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Ontology Term
PANTHER:PTHR10918 | HOMER
 
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Ontology Term
PANTHER:PTHR12694 | TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
 
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Ontology Term
PANTHER:PTHR12694:SF8 | TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
 
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Ontology Term
Pfam:PF03153 | Transcription factor IIA, alpha/beta subunit
Description: Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in Pfam:PF02268 and Pfam:PF02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step [1]. After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription.
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Ontology Term
Pfam:PF07990 | Nucleic acid binding protein NABP
Description: Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterised [1] and contains two putative phosphorylation sites and a possible dimerisation / leucine zipper domain.
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Ontology Term
Pfam:PF06547 | Protein of unknown function (DUF1117)
Description: This family represents the C-terminus of a number of hypothetical plant proteins.
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Ontology Term
Pfam:PF14369 | zinc-ribbon
Description: NULL
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Ontology Term
PANTHER:PTHR11040 | ZINC/IRON TRANSPORTER
 
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Ontology Term
PANTHER:PTHR12555 | UBIQUITIN FUSION DEGRADATON PROTEIN 1
 
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Ontology Term
Pfam:PF03152 | Ubiquitin fusion degradation protein UFD1
Description: Post-translational ubiquitin-protein conjugates are recognised for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified [1]. This family includes UFD1, a 40kD protein that is essential for vegetative cell viability [1]. The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterised by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated with these conditions are thought to be due to defective neural crest cell differentiation [2].
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Ontology Term
PANTHER:PTHR31032:SF1 | PGR5-LIKE PROTEIN 1B, CHLOROPLASTIC
 
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Ontology Term
PANTHER:PTHR21596 | RIBONUCLEASE P SUBUNIT P38
 
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