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Search results 3201 to 3300 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF12923 | Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain
Description: RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly [1]. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [1-2].
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Ontology Term
PANTHER:PTHR31828 | PHOSPHOLIPASE A1-IIGAMMA
 
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Ontology Term
Pfam:PF09585 | Conserved hypothetical protein (Lin0512_fam)
Description: This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a well conserved motif GxGxDxHG near the N-terminus.
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Ontology Term
PANTHER:PTHR12655 | ACYL-COA THIOESTERASE
 
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Ontology Term
Pfam:PF03061 | Thioesterase superfamily
Description: This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.
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Ontology Term
PANTHER:PTHR19288 | 4-NITROPHENYLPHOSPHATASE-RELATED
 
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Ontology Term
Pfam:PF13242 | HAD-hyrolase-like
Description: NULL
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Ontology Term
Pfam:PF13344 | Haloacid dehalogenase-like hydrolase
Description: This family is part of the HAD superfamily.
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Ontology Term
PANTHER:PTHR24322:SF58 | CARBONYL REDUCTASE 1-RELATED
 
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Ontology Term
PANTHER:PTHR31155 | ACYL- ACYL-CARRIER-PROTEIN DESATURASE-RELATED
 
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Ontology Term
Pfam:PF03405 | Fatty acid desaturase
Description: NULL
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Ontology Term
PANTHER:PTHR32295:SF0 | CALMODULIN BINDING PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR13077 | SELENOPROTEIN F
 
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Ontology Term
Pfam:PF08806 | Sep15/SelM redox domain
Description: Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif [1]. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum [1]. Structurally it resembles the thioredoxin-fold.
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Ontology Term
PANTHER:PTHR10774 | EXTENDED SYNAPTOTAGMIN-RELATED
 
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Ontology Term
Pfam:PF12428 | Protein of unknown function (DUF3675)
Description: This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00097. There are two completely conserved residues (R and L) that may be functionally important.
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Ontology Term
PANTHER:PTHR13227 | EUKARYOTIC TRANSLATION INITIATION FACTOR 2A
 
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Ontology Term
PANTHER:PTHR13227:SF0 | EUKARYOTIC TRANSLATION INITIATION FACTOR 2A
 
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Ontology Term
Pfam:PF08662 | Eukaryotic translation initiation factor eIF2A
Description: This is a family of eukaryotic translation initiation factors.
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Ontology Term
PANTHER:PTHR10133 | DNA POLYMERASE I
 
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Ontology Term
Pfam:PF01367 | 5'-3' exonuclease, C-terminal SAM fold
Description: NULL
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Ontology Term
Pfam:PF02739 | 5'-3' exonuclease, N-terminal resolvase-like domain
Description: NULL
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Ontology Term
Pfam:PF07145 | Ataxin-2 C-terminal region
Description: The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for Pfam:PF00658. It has been found in a wide range of eukaryotic proteins [1]. Strikingly, this motif appears to occur solely outside of globular domains [1].
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Ontology Term
Pfam:PF01738 | Dienelactone hydrolase family
Description: NULL
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Ontology Term
Pfam:PF09037 | Stf0 sulphotransferase
Description: Members of this family are essential for the biosynthesis of sulpholipid-1 in prokaryotes. They adopt a structure that belongs to the sulphotransferase superfamily, consisting of a single domain with a core four-stranded parallel beta-sheet flanked by alpha-helices [1].
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Ontology Term
PANTHER:PTHR13190 | AUTOPHAGY-RELATED 2, ISOFORM A
 
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Ontology Term
Pfam:PF09333 | Autophagy-related protein C terminal domain
Description: ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy [1].
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Ontology Term
PANTHER:PTHR31913 | VACUOLAR IMPORT AND DEGRADATION PROTEIN 27
 
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Ontology Term
PANTHER:PTHR31913:SF0 | VACUOLAR IMPORT AND DEGRADATION PROTEIN 27
 
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Ontology Term
Pfam:PF08553 | VID27 C-terminal WD40-like domain
Description: This is a family of fungal and plant proteins and contains many hypothetical proteins. VID27 is a cytoplasmic protein that plays a potential role in vacuolar protein degradation. This region is predicted to contain a WD40 repeat domain [1].
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Ontology Term
PANTHER:PTHR12560 | LONGEVITY ASSURANCE FACTOR 1 LAG1
 
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Ontology Term
Pfam:PF03798 | TLC domain
Description: NULL
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Ontology Term
PANTHER:PTHR32439 | FERREDOXIN--NITRITE REDUCTASE, CHLOROPLASTIC
 
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Ontology Term
PANTHER:PTHR32439:SF0 | FERREDOXIN--NITRITE REDUCTASE, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF01077 | Nitrite and sulphite reductase 4Fe-4S domain
Description: Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully. They are also both important for the dissimilation of oxidised anions for energy transduction.
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Ontology Term
Pfam:PF03460 | Nitrite/Sulfite reductase ferredoxin-like half domain
Description: Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidised anions for energy transduction [1]. Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain.
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Ontology Term
PANTHER:PTHR11929 | ALPHA- 1,3 -FUCOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF00852 | Glycosyltransferase family 10 (fucosyltransferase) C-term
Description: This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage [1]. This family is known as glycosyltransferase family 10 [2]. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).
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Ontology Term
PANTHER:PTHR11019 | HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
 
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Ontology Term
PANTHER:PTHR11019:SF4 | PROTEIN DJ-1
 
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Ontology Term
Pfam:PF01965 | DJ-1/PfpI family
Description: The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8.
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Ontology Term
PANTHER:PTHR22855:SF13 | METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF01039 | Carboxyl transferase domain
Description: All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognised types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide. All of the members in this family utilise acyl-CoA as the acceptor molecule.
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Ontology Term
Pfam:PF11347 | Protein of unknown function (DUF3148)
Description: This family of proteins has no known function.
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Ontology Term
PANTHER:PTHR14379 | LIMKAIN B LKAP
 
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Ontology Term
Pfam:PF01936 | NYN domain
Description: These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion, unlike the FLAP/5' --> 3' exonuclease superfamily, which binds two metal ions. Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.
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Ontology Term
Pfam:PF12872 | OST-HTH/LOTUS domain
Description: A predicted RNA-binding domain found in insect Oskar and vertebrate TDRD5/TDRD7 proteins that nucleate or organize structurally related ribonucleoprotein (RNP) complexes, the polar granule and nuage, is poorly understood [1][2]. The domain adopts the winged helix-turn- helix fold and bind RNA with a potential specificity for dsRNA [1].In eukaryotes this domain is often combined in the same polypeptide with protein-protein- or lipid- interaction domains that might play a role in anchoring these proteins to specific cytoskeletal structures. Thus, proteins with this domain might have a key role in the recognition and localization of dsRNA, including miRNAs, rasiRNAs and piRNAs hybridized to their targets. In other cases, this domain is fused to ubiquitin-binding, E3 ligase and ubiquitin-like domains indicating a previously under-appreciated role for ubiquitination in regulating the assembly and stability of nuage-like RNP complexes. Both bacteria and eukaryotes encode a conserved family of proteins that combines this predicted RNA-binding domain with a previously uncharacterized RNase domain belonging to the superfamily that includes the 5'->3' nucleases, PIN and NYN domains [1].
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Ontology Term
PANTHER:PTHR21569 | RIBOSOMAL PROTEIN S9
 
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Ontology Term
Pfam:PF00380 | Ribosomal protein S9/S16
Description: This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.
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Ontology Term
PANTHER:PTHR13145 | SSM4 PROTEIN
 
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Ontology Term
PANTHER:PTHR13145:SF0 | E3 UBIQUITIN-PROTEIN LIGASE MARCHF6
 
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Ontology Term
Pfam:PF00658 | Poly-adenylate binding protein, unique domain
Description: The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (Pfam:PF00076) [1]. Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.
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Ontology Term
PANTHER:PTHR31358:SF1 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR31865:SF0 | EXPRESSED PROTEIN
 
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Ontology Term
PANTHER:PTHR11467 | HISTONE H1
 
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Ontology Term
Pfam:PF00538 | linker histone H1 and H5 family
Description: Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.
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Ontology Term
PANTHER:PTHR10285:SF6 | URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG
 
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Ontology Term
Pfam:PF13207 | AAA domain
Description: NULL
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Ontology Term
Pfam:PF00485 | Phosphoribulokinase / Uridine kinase family
Description: This family matches three types of P-loop containing kinases: phosphoribulokinases [1], uridine kinases [2] and bacterial pantothenate kinases(CoaA) [3]. Arabidopsis and other organisms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain [4].
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Ontology Term
PANTHER:PTHR23284 | PROLACTIN REGULATORY ELEMENT BINDING PROTEIN
 
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Ontology Term
PANTHER:PTHR20883 | PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1
 
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Ontology Term
Pfam:PF05721 | Phytanoyl-CoA dioxygenase (PhyH)
Description: This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterised by the accumulation of phytanic acid in plasma and tissues [1].
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Ontology Term
PANTHER:PTHR10732 | 40S RIBOSOMAL PROTEIN S17
 
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Ontology Term
PANTHER:PTHR10732:SF0 | 40S RIBOSOMAL PROTEIN S17
 
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Ontology Term
Pfam:PF00833 | Ribosomal S17
Description: NULL
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Ontology Term
Pfam:PF03417 | Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Description: NULL
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Ontology Term
PANTHER:PTHR11583 | VACUOLAR ATP SYNTHASE SUBUNIT E
 
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Ontology Term
Pfam:PF06697 | Protein of unknown function (DUF1191)
Description: This family contains hypothetical plant proteins of unknown function.
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Ontology Term
Pfam:PF08991 | Mature-T-Cell Proliferation I type
Description: Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold [3]. The precise function of this eukaryotic domain is, as yet, unknown [1]. MTCP1 is found in mitochondria. Mature-T-Cell Proliferation) is the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype [2].
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Ontology Term
Pfam:PF12159 | Protein of unknown function (DUF3593)
Description: This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 98 and 228 amino acids in length. There is a conserved LHG sequence motif.
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Ontology Term
PANTHER:PTHR13136 | TESTIS DEVELOPMENT PROTEIN PRTD
 
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Ontology Term
Pfam:PF12695 | Alpha/beta hydrolase family
Description: This family contains a diverse range of alpha/beta hydrolase enzymes.
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Ontology Term
Pfam:PF09478 | Carbohydrate binding domain CBM49
Description: This domain is found at the C terminal of cellulases and in vitro binding studies have shown it to binds to crystalline cellulose [1].
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Ontology Term
PANTHER:PTHR11349 | NUCLEOSIDE DIPHOSPHATE KINASE
 
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Ontology Term
Pfam:PF00334 | Nucleoside diphosphate kinase
Description: NULL
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Ontology Term
PANTHER:PTHR32166 | OSJNBA0013A04.12 PROTEIN
 
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Ontology Term
Pfam:PF04937 | Protein of unknown function (DUF 659)
Description: Transposase-like protein with no known function.
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Ontology Term
PANTHER:PTHR12446 | TESMIN/TSO1-RELATED
 
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Ontology Term
PANTHER:PTHR10168:SF44 | GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED
 
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Ontology Term
Pfam:PF10539 | Development and cell death domain
Description: The DCD domain is found in plant proteins involved in development and cell death. The DCD domain is an approximately 130 amino acid long stretch that contains several mostly invariable motifs. These include a FGLP and a LFL motif at the N-terminus and a PAQV and a PLxE motif towards the C-terminus of the domain. The DCD domain is present in proteins with different architectures. Some of these proteins contain additional recognisable motifs, like the KELCH repeats or the ParB domain.
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Ontology Term
Pfam:PF02801 | Beta-ketoacyl synthase, C-terminal domain
Description: The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
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Ontology Term
PANTHER:PTHR21011 | MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6
 
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Ontology Term
PANTHER:PTHR21011:SF1 | 28S RIBOSOMAL PROTEIN S6, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF01250 | Ribosomal protein S6
Description: NULL
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Ontology Term
Pfam:PF10382 | Protein of unknown function (DUF2439)
Description: This domain can be found in proteins that have been implicated in telomere maintenance in Saccharomyces cerevisiae [1] and in meiotic chromosome segregation in Schizosaccharomyces pombe [2]. It can also be found in Mte1 (Mph1-associated telomere maintenance protein 1), human zinc finger protein ZGRF1 (C4ORF21) and fission yeast Dbl2 [3]. Mte1 is a D-loop-binding protein that interacts and stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Mph1 and Mte1 interdependently colocalise at DNA damage-induced foci and dysfunctional telomeres. Mte1 is indicated to play a role in regulation of crossover recombination, response to replication stress, and telomere maintenance [4]. The fission yeast, Dbl2 is needed for cellular resistance to the topoisomerase I poison camptothecin, forms DNA damage-induced foci, and is needed for the optimal recruitment of Fml1 to DNA damage, while the human ZGRF1 protein has been linked to DNA cross-link repair and mutations of it have been found in a variety of human tumors [5]. ZGRF1 is a 5'-to-3'helicase that interacts with RAD51 and stimulates homologous recombination and, thus, promotes the repair of replication-blocking DNA lesions [6]. Having said that, there is no evidence to suggest that this domain is implicated in DNA damage resistance or for nuclear focus formation [3].
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Ontology Term
PANTHER:PTHR19959 | KINESIN LIGHT CHAIN
 
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Ontology Term
Pfam:PF13374 | Tetratricopeptide repeat
Description: NULL
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Ontology Term
PANTHER:PTHR10527:SF1 | IMPORTIN SUBUNIT BETA-1
 
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Ontology Term
PANTHER:PTHR23090 | NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE
 
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Ontology Term
Pfam:PF02540 | NAD synthase
Description: NAD synthase (EC:6.3.5.1) is involved in the de novo synthesis of NAD and is induced by stress factors such as heat shock and glucose limitation.
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Ontology Term
PANTHER:PTHR24322:SF17 | RIBITOL DEHYDROGENASE-LIKE
 
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Ontology Term
PANTHER:PTHR14221:SF0 | WD REPEAT-CONTAINING PROTEIN 44
 
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Ontology Term
PANTHER:PTHR12225 | ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN
 
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Ontology Term
PANTHER:PTHR12225:SF0 | PROTEASOMAL UBIQUITIN RECEPTOR ADRM1
 
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Ontology Term
Pfam:PF04683 | Proteasome complex subunit Rpn13 ubiquitin receptor
Description: This family was thought originally to be involved in cell-adhesion [1,2], but the members are now known to be proteasome subunit Rpn13, a novel ubiquitin receptor. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain [4]. The domain forms two contiguous anti-parallel beta-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold [5]. Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37 [5].
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Ontology Term
PANTHER:PTHR11142 | PSEUDOURIDYLATE SYNTHASE
 
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Ontology Term
Pfam:PF01416 | tRNA pseudouridine synthase
Description: Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.
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Ontology Term
PANTHER:PTHR11752 | HELICASE SKI2W
 
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Ontology Term
Pfam:PF08148 | DSHCT (NUC185) domain
Description: This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases [1].
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Ontology Term
Pfam:PF13234 | rRNA-processing arch domain
Description: Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [1].
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